ADGRB3

This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]

Full Name

Adhesion G Protein-Coupled Receptor B3

Function

Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Maintenance of synapse structure
Motor learning
Myoblast fusion
Negative regulation of angiogenesis
Neuron remodeling
Positive regulation of synapse assembly
Regulation of dendrite morphogenesis

Cellular Location

Cell membrane

Topology

Extracellular: 25-880 aa
Helical: 881-901 aa
Cytoplasmic: 902-910 aa
Helical: 911-931 aa
Extracellular: 932-939 aa
Helical: 940-960 aa
Cytoplasmic: 961-981 aa
Helical: 982-1002 aa
Extracellular: 1003-1023 aa
Helical: 1024-1044 aa
Cytoplasmic: 1045-1098 aa
Helical: 1099-1119 aa
Extracellular: 1120-1125 aa
Helical: 1126-1146 aa
Cytoplasmic: 1147-1522 aa

PTM

The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

Anti-ADGRB3 antibodies

Mouse Anti-ADGRB3 Recombinant Antibody (V2-51280) (CBMAB-2088-YY)

Datasheet

SDS

Target: ADGRB3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-51280

Application*: IH, WB

Mouse Anti-ADGRB3 Recombinant Antibody (V2-51279) (CBMAB-2087-YY)

Datasheet

SDS

Target: ADGRB3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-51279

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)