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ANPEP

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
Full Name
Alanyl Aminopeptidase, Membrane
Function
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.
(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.
Biological Process
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Neutrophil degranulation Source: Reactome
Peptide catabolic process Source: GO_Central
Proteolysis Source: GO_Central
Regulation of blood pressure Source: GO_Central
Signal transduction Source: GO_Central
Cellular Location
Cell membrane. Also found as a soluble form.
Topology
Cytoplasmic: 2-8 aa
Helical: 9-32 aa
Extracellular: 33-967 aa
PTM
Sulfated.
N- and O-glycosylated.
May undergo proteolysis and give rise to a soluble form.

Anti-ANPEP antibodies

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Target: ANPEP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G1
Application*: E
Target: ANPEP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 22A5
Application*: FC, IH, IP
Target: ANPEP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A2844
Application*: E, WB, IH
Target: ANPEP
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 123H1
Application*: FC, IP
Target: ANPEP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: ER-BMDM1
Application*: FC, IH
Target: ANPEP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: R3-63
Application*: FC, IF, IC, IH
Target: ANPEP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: WM15
Application*: FC, IH, IF, IP
Target: ANPEP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A619
Application*: WB, IP, IF, P
Target: ANPEP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-A620
Application*: E, WB, IP, IF, P
Target: ANPEP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1
Application*: E
Target: ANPEP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 122
Application*: E, WB, P
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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