CERS6

CERS6 (Ceramide Synthase 6) is a Protein Coding gene.

Ceramide Synthase 6

Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624).
Can use other acyl donors, but with less efficiency (By similarity).
Ceramides generated by CERS6 play a role in inflammatory response (By similarity).
Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity).
Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity).

Ceramide biosynthetic process Source: UniProtKB
Inflammatory response Source: UniProtKB-KW
Sphingolipid biosynthetic process Source: Reactome

Endoplasmic reticulum membrane

Lumenal: 1-34
Helical: 35-55
Helical: 178-198
Helical: 205-225
Helical: 263-283
Helical: 303-323
Cytoplasmic: 324-384

Phosphorylated at the C-terminus by CK2.
Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.