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CLIC1

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
Full Name
CLIC1
Function
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Biological Process
Chloride transport Source: MGI
Glutathione metabolic process Source: InterPro
Platelet aggregation Source: UniProtKB
Positive regulation of osteoblast differentiation Source: Ensembl
Regulation of cell cycle Source: InterPro
Regulation of ion transmembrane transport Source: UniProtKB-KW
Regulation of mitochondrial membrane potential Source: Ensembl
Signal transduction Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasm; Nucleus; Nucleus membrane. Mostly in the nucleus including in the nuclear membrane (PubMed:9139710, PubMed:12681486). Small amount in the cytoplasm and the plasma membrane (PubMed:9139710). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11940526, PubMed:11551966, PubMed:14613939).
Topology
Helical: 26-46
PTM
Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.

Anti-CLIC1 antibodies

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Target: CLIC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5BA5
Application*: E, P, IH, M, WB
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5BA4
Application*: E, P, IH
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C3156
Application*: E, WB, IH
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1075
Application*: E, WB
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1074
Application*: E, WB
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-213
Application*: E, WB
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNC-212
Application*: E, WB, P
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNC-211
Application*: E, WB, P
Target: CLIC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D7D6H
Application*: WB, IP
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3F9
Application*: E, P, WB
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D4
Application*: E, P, WB
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 11C234
Application*: C, WB
Target: CLIC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-358
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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