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CXCR5

CXCR5 (C-X-C Motif Chemokine Receptor 5) is a Protein Coding gene. Diseases associated with CXCR5 include Burkitt Lymphoma and Lymphoma. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CXCR3.

Full Name

C-X-C Motif Chemokine Receptor 5

Function

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Biological Process

B cell activation Source: UniProtKB-KW
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Leukocyte chemotaxis Source: Ensembl
Lymph node development Source: Ensembl
Positive regulation of cytokinesis Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-55
Helical: 56-76
Cytoplasmic: 77-88
Helical: 89-109
Extracellular: 110-124
Helical: 125-145
Cytoplasmic: 146-167
Helical: 168-188
Extracellular: 189-219
Helical: 220-240
Cytoplasmic: 241-259
Helical: 260-280
Extracellular: 281-304
Helical: 305-325
Cytoplasmic: 326-372

Anti-CXCR5 antibodies

Mouse Anti-CXCR5 Recombinant Antibody (51505) (CBMAB-C2953-LY)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 51505

Application*: F, IH, N, IC, MC

Mouse Anti-CXCR5 Recombinant Antibody (51505.111) (CBMAB-C2958-LY)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 51505.111

Application*: F

Rabbit Anti-CXCR5 Recombinant Antibody (6H35L3) (CBMAB-C8351-LY)

SDS

Target: CXCR5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 6H35L3

Application*: WB

Mouse Anti-CXCR5 Recombinant Antibody (8C17) (CBMAB-C9077-LY)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 8C17

Application*: F, IH, N

Rabbit Anti-CXCR5 Recombinant Antibody (CBYY-C2372) (CBMAB-C3810-YY)

SDS

Target: CXCR5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-C2372

Application*: WB

Mouse Anti-CXCR5 Recombinant Antibody (CBYY-C2373) (CBMAB-C3811-YY)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYY-C2373

Application*: F, IH, N

Mouse Anti-CXCR5 Recombinant Antibody (14L332) (CBMAB-C3254-CN)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 14L332

Application*: FC, IH, N

Mouse Anti-CXCR5 Recombinant Antibody (MU5UBEE) (CBMAB-C11415-LY)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Monkey

Clone: MU5UBEE

Application*: F

Rat Anti-CXCR5 Recombinant Antibody (SPRCL5) (CBMAB-C11417-LY)

SDS

Target: CXCR5

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: SPRCL5

Application*: F

Mouse Anti-CXCR5 Recombinant Antibody (MM0225-8C17) (CBMAB-C11418-LY)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: MM0225-8C17

Application*: WB, C, F

Rabbit Anti-CXCR5 Recombinant Antibody (D6L3C) (CBMAB-CP0404-LY)

SDS

Target: CXCR5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D6L3C

Application*: P

Rat Anti-CXCR5 Recombinant Antibody (614641) (CBMAB-C7872-LY)

SDS

Target: CXCR5

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 614641

Application*: F, IC, MC

Rat Anti-CXCR5 Recombinant Antibody (CBYY-I0027) (CBMAB-I0055-YY)

SDS

Target: CXCR5

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBYY-I0027

Application*: F

Rat Anti-CXCR5 Recombinant Antibody (CBYY-I0028) (CBMAB-I0056-YY)

SDS

Target: CXCR5

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBYY-I0028

Application*: F, C

Mouse Anti-CXCR5 Recombinant Antibody (CBXC-2582) (CBMAB-C0254-CQ)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-2582

Application*: F

Mouse Anti-CXCR5 Recombinant Antibody (CBXC-3086) (CBMAB-C0935-CQ)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXC-3086

Application*: WB, F, IH, C, MC

Mouse Anti-CXCR5 Recombinant Antibody (CBXC-1229) (CBMAB-C1496-CQ)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-1229

Application*: F

Human Anti-CXCR5 Recombinant Antibody (CBXC-0705) (CBMAB-C1818-CQ)

SDS

Target: CXCR5

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0705

Application*: F

Human Anti-CXCR5 Recombinant Antibody (CBXC-0750) (CBMAB-C1864-CQ)

SDS

Target: CXCR5

Host: Human

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXC-0750

Application*: F

Rat Anti-CXCR5 Recombinant Antibody (CBXC-1408) (CBMAB-C3586-CQ)

SDS

Target: CXCR5

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXC-1408

Application*: E, F, IC

Rabbit Anti-CXCR5 Recombinant Antibody (CBWJC-2099) (CBMAB-C2793WJ)

SDS

Target: CXCR5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBWJC-2099

Application*: WB, IC, F

Mouse Anti-CXCR5 Recombinant Antibody (CBWJC-3500) (CBMAB-C4731WJ)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJC-3500

Application*: F

Rat Anti-CXCR5 Recombinant Antibody (CBWJC-3501) (CBMAB-C4732WJ)

SDS

Target: CXCR5

Host: Rat

Antibody Isotype: IgG2b, κ

Specificity: Mouse

Clone: CBWJC-3501

Application*: F

Mouse Anti-CXCR5 Recombinant Antibody (2C1) (CBMAB-C4742-LY)

SDS

Target: CXCR5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2C1

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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