DSCC1

CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

Full Name

DNA Replication And Sister Chromatid Cohesion 1

Research Area

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

Biological Process

DNA duplex unwinding Source: GOC
DNA replication Source: UniProtKB-KW
Maintenance of mitotic sister chromatid cohesion Source: UniProtKB
Positive regulation of DNA-directed DNA polymerase activity Source: UniProtKB
Post-translational protein acetylation Source: UniProtKB
Regulation of DNA replication Source: UniProtKB

Cellular Location

Nucleus

Anti-DSCC1 antibodies

Mouse Anti-DSCC1 Recombinant Antibody (V76P1B2/B12) (CBMAB-D1730-YC)

Datasheet

SDS

Target: DSCC1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: V76P1B2/B12

Application*: WB, E, IH

Recombinant Mouse Anti-DSCC1 Recombinant Antibody (P1B2) (CBMAB-XB0367-YC)

Datasheet

SDS

Target: DSCC1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: P1B2

Application*: E, IH, WB

Mouse Anti-DSCC1 Recombinant Antibody (B12) (CBMAB-AP1949LY)

Datasheet

SDS

Target: DSCC1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: B12

Application*: ELISA, IHC, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)