GTPBP4

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.

GTP binding protein 4

Involved in the biogenesis of the 60S ribosomal subunit.

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
Negative regulation of cell-cell adhesion Source: HGNC-UCL
Negative regulation of cell migration Source: HGNC-UCL
Negative regulation of cell population proliferation Source: HGNC-UCL
Negative regulation of collagen binding Source: HGNC-UCL
Negative regulation of DNA replication Source: HGNC-UCL
Negative regulation of protein ubiquitination Source: HGNC-UCL
Osteoblast differentiation Source: UniProtKB
Protein stabilization Source: HGNC-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC-UCL

Nucleolus