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LMTK3

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. LMTK3 may also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. LMTK3 is involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

Full Name

lemur tyrosine kinase 3

Function

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804).
Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

Biological Process

Protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane
Cell projection, axon
Cell projection, dendrite
Golgi apparatus membrane
Punctate pattern in cell projections.

Topology

Helical: 40-60

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Anti-LMTK3 antibodies

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Mouse Anti-LMTK3 Recombinant Antibody (CBYCL-407) (CBMAB-L0308-YC)

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Target: LMTK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCL-407

Application*: E, WB

Mouse Anti-LMTK3 Recombinant Antibody (CBYCL-406) (CBMAB-L0307-YC)

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Target: LMTK3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYCL-406

Application*: E, WB

Mouse Anti-LMTK3 Recombinant Antibody (6C5) (CBMAB-L1896-YJ)

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Target: LMTK3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 6C5

Application*: WB

Mouse Anti-LMTK3 Recombinant Antibody (CBYJL-1889) (CBMAB-L1894-YJ)

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Target: LMTK3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJL-1889

Application*: WB

Mouse Anti-LMTK3 Recombinant Antibody (CBYJL-1888) (CBMAB-L1893-YJ)

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Target: LMTK3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJL-1888

Application*: E, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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