LRMP

Jaw1, also known as lymphoid‐restricted membrane protein (LRMP), is an endoplasmic reticulum‐associated protein.

LYMPHOID-RESTRICTED MEMBRANE PROTEIN

Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules.

Immune system processIEA:UniProtKB-KW
Nucleus organizationISS:UniProtKB
Single fertilizationIEA:UniProtKB-KW
Vesicle fusionManual Assertion Based On ExperimentTAS:ProtInc
Vesicle targetingManual Assertion Based On ExperimentTAS:ProtInc

Processed inositol 1,4,5-triphosphate receptor associated 2:
Cytoplasm
Endoplasmic reticulum membrane
Nucleus envelope
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle pole
Chromosome
Colocalized with ITPR3 on the endoplasmic reticulum membrane.

Cytoplasmic: 1-495
Helical: 496-516
Lumenal: 517-555

The removal of the C-terminal lumenal domain occurs by proteolytic processing.