MAP2K5

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq]

mitogen-activated protein kinase kinase 5

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

Cellular response to growth factor stimulusBy SimilarityISS:BHF-UCL
Cellular response to laminar fluid shear stressManual Assertion Based On ExperimentTAS:BHF-UCL
ERK5 cascadeIEA:Ensembl
Heart developmentIEA:Ensembl
MAPK cascadeManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell migration involved in sprouting angiogenesisBy SimilarityISS:BHF-UCL
Negative regulation of chemokine (C-X-C motif) ligand 2 productionBy SimilarityISS:BHF-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processBy SimilarityISS:BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandBy SimilarityISS:BHF-UCL
Negative regulation of heterotypic cell-cell adhesionBy SimilarityISS:BHF-UCL
Negative regulation of interleukin-8 productionBy SimilarityISS:BHF-UCL
Negative regulation of NF-kappaB transcription factor activityBy SimilarityISS:BHF-UCL
Negative regulation of response to cytokine stimulusBy SimilarityISS:BHF-UCL
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of cell growthIEA:Ensembl
Positive regulation of epithelial cell proliferationIEA:Ensembl
Positive regulation of MAP kinase activityBy SimilarityISS:BHF-UCL
Positive regulation of protein metabolic processISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cytosol
Nucleus
Spindle

Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
(Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.