PARVA

This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]

Full Name

Parvin Alpha

Function

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity).
Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIBA:GO_Central
Actin-mediated cell contractionISS:UniProtKB
Cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Establishment or maintenance of cell polarityISS:UniProtKB
Heterotypic cell-cell adhesionISS:UniProtKB
Outflow tract septum morphogenesisISS:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of cell shapeIEA:UniProtKB-KW
Smooth muscle cell chemotaxisISS:UniProtKB
Sprouting angiogenesisISS:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell junction, focal adhesion
Cell membrane
Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, Z line
Constituent of focal adhesions. Associates with the actin cytoskeleton.