PARVA

This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]
Full Name
Parvin Alpha
Function
Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity).
Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIBA:GO_Central
Actin-mediated cell contractionISS:UniProtKB
Cell projection assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Establishment or maintenance of cell polarityISS:UniProtKB
Heterotypic cell-cell adhesionISS:UniProtKB
Outflow tract septum morphogenesisISS:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of cell shapeIEA:UniProtKB-KW
Smooth muscle cell chemotaxisISS:UniProtKB
Sprouting angiogenesisISS:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell junction, focal adhesion
Cell membrane
Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, Z line
Constituent of focal adhesions. Associates with the actin cytoskeleton.
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Anti-PARVA antibodies

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Rabbit Anti-PARVA Recombinant Antibody (D7F9) (CBMAB-P0830-YC)

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Target: PARVA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Dog
Clone: D7F9
Application*: IP
Datasheet SDS

Mouse Anti-PARVA Recombinant Antibody (3H9) (CBMAB-P0829-YC)

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Target: PARVA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H9
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-PARVA Recombinant Antibody (1H2) (CBMAB-P0827-YC)

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Target: PARVA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1H2
Application*: E, LA
Datasheet SDS

Mouse Anti-PARVA Recombinant Antibody (1C11) (CBMAB-P0826-YC)

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Target: PARVA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1C11
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-PARVA Recombinant Antibody (1C10) (CBMAB-A4652-YC)

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Target: PARVA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey
Clone: 1C10
Application*: WB, IH, IF
Datasheet SDS

Human Recombinant PARVA protein, Biotin Conjugated, GST Tag (V2LY-0526-LY5977)

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Target: PARVA
Expressed Host: E. coli
Sequence: Amino Acid: 1-372
Tag: GST Tag
Datasheet SDS

Human Recombinant PARVA protein, GST Tag (V2LY-0526-LY5976)

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Target: PARVA
Expressed Host: E. coli
Sequence: Amino Acid: 1-372
Tag: GST Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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