Phospho-CCNB1 (Ser133)

CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include Thyroid Lymphoma and Adrenal Carcinoma. Among its related pathways are Mitotic Prometaphase and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein kinase binding and patched binding. An important paralog of this gene is CCNB2.

Cyclin B1

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Anaphase-promoting complex-dependent catabolic process Source: Reactome
Cell division Source: UniProtKB-KW
Cellular response to fatty acid Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Cellular response to iron(III) ion Source: Ensembl
Cellular response to organic cyclic compound Source: Ensembl
Digestive tract development Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Histone H3-S10 phosphorylation involved in chromosome condensation Source: Ensembl
In utero embryonic development Source: Ensembl
Mitotic cell cycle phase transition Source: GO_Central
Mitotic chromosome condensation Source: Reactome
Mitotic metaphase plate congression Source: BHF-UCL
Mitotic nuclear envelope disassembly Source: Reactome
Mitotic nuclear envelope reassembly Source: Reactome
Mitotic spindle organization Source: BHF-UCL
Negative regulation of gene expression Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Oocyte maturation Source: Ensembl
Positive regulation of attachment of spindle microtubules to kinetochore Source: BHF-UCL
Positive regulation of cardiac muscle cell proliferation Source: Ensembl
Positive regulation of fibroblast proliferation Source: Ensembl
Positive regulation of G2/M transition of mitotic cell cycle Source: CAFA
Positive regulation of histone phosphorylation Source: Ensembl
Positive regulation of mitochondrial ATP synthesis coupled electron transport Source: CAFA
Positive regulation of mitotic cell cycle Source: BHF-UCL
Positive regulation of mRNA 3'-end processing Source: Ensembl
Protein-containing complex assembly Source: Ensembl
Regulation of cell cycle Source: Reactome
Regulation of chromosome condensation Source: Ensembl
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of mitotic cell cycle phase transition Source: Reactome
Regulation of mitotic cell cycle spindle assembly checkpoint Source: BHF-UCL
Regulation of transcription initiation from RNA polymerase II promoter Source: Reactome
Response to DDT Source: Ensembl
Response to drug Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Rpermatogenesis Source: Ensembl
Tissue regeneration Source: Ensembl
Ventricular cardiac muscle cell development Source: Ensembl

Centrosome; Cytoplasm; Nucleus

Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.