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PPP3CA

PPP3CA (Protein Phosphatase 3 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PPP3CA include Epileptic Encephalopathy, Infantile Or Early Childhood, 1 and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and enzyme binding. An important paralog of this gene is PPP3CB.
Full Name
protein phosphatase 3 catalytic subunit alpha
Function
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591, PubMed:30254215).
Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:22343722, PubMed:23468591, PubMed:27974827).
In response to increased Ca2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020).
In response to increased Ca2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687).
Positively regulates the CACNA1B/CAV2.2-mediated Ca2+ release probability at hippocampal neuronal soma and synaptic terminals (By similarity).
Dephosphorylates heat shock protein HSPB1 (By similarity).
Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138).
In response to increased Ca2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042).
Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138).
Dephosphorylates DARPP32 (PubMed:19154138).
May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed:30611118).
Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed:33691586).
Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity).
Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity).
Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity).
Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity).
Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity).
Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity).
Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity).
May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity).
Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity).
Required for antigen-specific T-cell proliferation response (By similarity).
Biological Process
AgingIEA:Ensembl
Brain developmentIEA:Ensembl
Calcineurin-mediated signalingManual Assertion Based On ExperimentIMP:UniProtKB
Calcineurin-NFAT signaling cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Calcium ion transportIEA:Ensembl
Cardiac muscle hypertrophy in response to stressIEA:Ensembl
Cellular response to glucose stimulusIEA:Ensembl
Dendrite morphogenesisIEA:Ensembl
DephosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Epidermis developmentISS:UniProtKB
Excitatory postsynaptic potentialIEA:Ensembl
G1/S transition of mitotic cell cycleIEA:Ensembl
Keratinocyte differentiationISS:UniProtKB
Modulation of chemical synaptic transmissionISS:UniProtKB
Multicellular organismal response to stressIEA:Ensembl
Negative regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Negative regulation of chromatin bindingIEA:Ensembl
Negative regulation of dendrite morphogenesisIEA:Ensembl
Negative regulation of insulin secretionIEA:Ensembl
Negative regulation of miRNA maturationIEA:Ensembl
Negative regulation of signalingISS:UniProtKB
Negative regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Peptidyl-serine dephosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of activated T cell proliferationISS:UniProtKB
Positive regulation of calcineurin-NFAT signaling cascade2 PublicationsIC:ComplexPortal
Positive regulation of calcium ion import across plasma membrane1 PublicationIC:ComplexPortal
Positive regulation of cardiac muscle hypertrophy in response to stressIEA:Ensembl
Positive regulation of cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of connective tissue replacementIEA:Ensembl
Positive regulation of DNA-binding transcription factor activityIEA:Ensembl
Positive regulation of endocytosisIEA:Ensembl
Positive regulation of glomerulus developmentISS:UniProtKB
Positive regulation of osteoblast differentiationISS:UniProtKB
Positive regulation of osteoclast differentiationISS:UniProtKB
Positive regulation of saliva secretionISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of voltage-gated calcium channel activity1 PublicationIC:ComplexPortal
Postsynaptic modulation of chemical synaptic transmissionIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein import into nucleusIEA:Ensembl
Regulation of cell proliferation involved in kidney morphogenesisISS:UniProtKB
Renal filtrationISS:UniProtKB
Response to amphetamineIEA:Ensembl
Response to calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Skeletal muscle fiber developmentISS:UniProtKB
Skeletal muscle tissue regenerationManual Assertion Based On ExperimentTAS:BHF-UCL
T cell activationManual Assertion Based On ExperimentTAS:UniProtKB
Transition between fast and slow fiberIEA:Ensembl
Wound healingManual Assertion Based On ExperimentTAS:BHF-UCL
Keywords
Cellular Location
Cytoplasm
Cell membrane
Cell membrane, sarcolemma
Cytoplasm, myofibril, sarcomere, Z line
Cell projection, dendritic spine
Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity).
Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca2+-channel activation (PubMed:22343722).
Involvement in disease
Epileptic encephalopathy, infantile or early childhood, 1 (IECEE1):
A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. IECEE1 is an autosomal dominant condition with onset of seizures between the first weeks and first years of life.
Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development (ACCIID):
An autosomal dominant disease characterized by moderate to severe intellectual disability, craniosynostosis, cleft palate, micrognathia, arthrogryposis, and short stature. Some patients may present bone abnormalities and generalized seizures.

Anti-PPP3CA antibodies

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Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CC-6
Application*: IP
Target: PPP3CA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster
Clone: CBYC-P578
Application*: WB, IP, F
Target: PPP3CA
Host: Rabbit
Antibody Isotype: IgG1
Specificity: Rat, Rabbit
Clone: CBLC255-LY
Application*: E, WB, P, IF/IC, IP
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Rat
Application*: ELISA, WB, IHC
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Chicken, Frog, Mouse
Clone: 29/Calcineurin
Application*: WB, IF, IH
Target: PPP3CA
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 302202
Application*: WB
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 10K119
Application*: WB, IP, IH
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Rabbit, Rat
Clone: 15j6
Application*: E, IC, IH, IP, WB
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: 2E2.D11
Application*: WB, P, C
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G8
Application*: E, C, WB
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Rat
Clone: 7C21
Application*: E, WB
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-3049
Application*: WB, IP, IH
Target: PPP3CA
Host: Mouse
Specificity: Cattle, Rabbit, Rat
Clone: CBFYC-3050
Application*: E, IC, IH, IP, WB
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Chicken, Frog, Human, Mouse
Clone: CBFYC-3051
Application*: WB, IF, IH
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Frog
Clone: CBWJC-2374
Application*: WB, E
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Frog
Clone: CBWJC-2375
Application*: WB, E
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Cattle, Human
Clone: CBWJC-4310
Application*: WB, E, P
Target: PPP3CA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Hamster, Human
Clone: CBWJC-4311
Application*: WB, IP, F
Target: PPP3CA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4313
Application*: WB, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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