SIGLEC7
SIGLEC7 (Sialic Acid Binding Ig Like Lectin 7) is a Protein Coding gene. Diseases associated with SIGLEC7 include Pheochromocytoma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC12.
Full Name
sialic acid binding Ig-like lectin 7
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Biological Process
Cell adhesion
Cellular Location
Membrane
Topology
Extracellular: 19-353
Helical: 354-376
Cytoplasmic: 377-467
Helical: 354-376
Cytoplasmic: 377-467
PTM
Tyrosine phosphorylated.
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Anti-SIGLEC7 antibodies
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CompareTarget: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3049
Application*: IH, F
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2405
Application*: F
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2404
Application*: F, IP
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3475
Application*: F, IH
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3126
Application*: E, WB
Target: SIGLEC7
Host: Mouse
Specificity: Human
Clone: CBXS-2034
Application*: WB, IP, IF, E
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1692
Application*: WB
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0370
Application*: F, C, P
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3799
Application*: WB
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3790
Application*: WB
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXS-5930
Application*: IH, WB
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5718
Application*: F, C
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5782
Application*: F, MC
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2975
Application*: F
Target: SIGLEC7
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0749
Application*: F
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5-386
Application*: C, F
Target: SIGLEC7
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0551-8D8
Application*: WB, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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