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UBQLN4

Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).

Anti-UBQLN4 antibodies

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Cat Product Name Target Host Antibody Isotype Cross Reactivity Clone Application*
PEP-192580CQ Mouse UBQLN4 Peptide (TPKDKEEIVICDQASVK) UBQLN4
PEP-192579CQ Mouse UBQLN4 Peptide (SPPSTPDSASAPSTTPASPA) UBQLN4
PEP-156946CQ Human UBQLN4 Peptide (SPSATASIL) UBQLN4
PEP-192578CQ Mouse UBQLN4 Peptide (NREANLQALIATG) UBQLN4
PEP-192577CQ Mouse UBQLN4 Peptide (INREANLQALIATGGD) UBQLN4
PEP-192576CQ Mouse UBQLN4 Peptide (INREANLQALIATG) UBQLN4
PEP-192575CQ Mouse UBQLN4 Peptide (FINREANLQALIATG) UBQLN4
PEP-192574CQ Mouse UBQLN4 Peptide (APSTTPASPAAAPVQ) UBQLN4
PEP-156945CQ Human UBQLN4 Peptide (QLMSNPEM) UBQLN4
PEP-156944CQ Human UBQLN4 Peptide (APYMRSMMQTL) UBQLN4
PEP-156943CQ Human UBQLN4 Peptide (SIPGGYNALR) UBQLN4
PEP-156942CQ Human UBQLN4 Peptide (DGLTVHLVI) UBQLN4
PEP-156941CQ Human UBQLN4 Peptide (APYMRSMM) UBQLN4
PEP-156940CQ Human UBQLN4 Peptide (PYMRSMMQTL) UBQLN4
PEP-156939CQ Human UBQLN4 Peptide (MYTDIQEPMF) UBQLN4
PEP-156938CQ Human UBQLN4 Peptide (SVKEFKEEI) UBQLN4
PEP-061730CQ Human UBQLN4 Peptide (SPSATASILSGF) UBQLN4
PEP-061729CQ Human UBQLN4 Peptide (QLMERNPEI) UBQLN4
PEP-061728CQ Human UBQLN4 Peptide (QLMQQMIQL) UBQLN4
PEP-061727CQ Human UBQLN4 Peptide (RRFKAQQDQL) UBQLN4
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)