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UBXN6

May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).

Anti-UBXN6 antibodies

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Cat Product Name Target Host Antibody Isotype Cross Reactivity Clone Application*
CBMAB-C4426-CN Mouse Anti-UBXN6 Recombinant Antibody (9E105) UBXN6 Mouse IgG Human 9E105 IF, IP, WB
CBMAB-C4425-CN Mouse Anti-UBXN6 Recombinant Antibody (9E104) UBXN6 Mouse IgG Human 9E104 IF, IP, WB
CBMAB-C4424-CN Mouse Anti-UBXN6 Recombinant Antibody (5C3-1) UBXN6 Mouse IgG1 Human 5C3-1 WB, IP, IF
CBMAB-C4423-CN Mouse Anti-UBXN6 Recombinant Antibody (2F8-24) UBXN6 Mouse IgG1 Human, Mouse 2F8-24 WB, IP, IF
PEP-192619CQ Mouse UBXN6 Peptide (LPSDFFSLTAEEVKREQ) UBXN6
PEP-192618CQ Mouse UBXN6 Peptide (LPSDFFSLTAEEVKRE) UBXN6
PEP-192617CQ Mouse UBXN6 Peptide (LPSDFFSLTAEEVKR) UBXN6
PEP-153732CQ Human UBXN6 Peptide (QEDPEEFYVL) UBXN6
PEP-153731CQ Human UBXN6 Peptide (VYGFVREAL) UBXN6
PEP-153730CQ Human UBXN6 Peptide (ERLGAVYGF) UBXN6
PEP-061886CQ Human UBXN6 Peptide (EEQRGLRKY) UBXN6
PEP-061885CQ Human UBXN6 Peptide (EEIKREQRL) UBXN6
PEP-061884CQ Human UBXN6 Peptide (APRPPRQGP) UBXN6
PEP-061883CQ Human UBXN6 Peptide (VFQPSPLASQF) UBXN6
PEP-061882CQ Human UBXN6 Peptide (KEKPNQPAP) UBXN6
PEP-061881CQ Human UBXN6 Peptide (HEFFEAIGF) UBXN6
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)