CLASP1

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

Full Name

Cytoplasmic Linker Associated Protein 1

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Biological Process

Astral microtubule organization Source: UniProtKB
Cell division Source: MGI
Ciliary basal body-plasma membrane docking Source: Reactome
Establishment of epithelial cell polarity Source: UniProtKB
Establishment of mitotic spindle localization Source: UniProtKB
Establishment of spindle orientation Source: MGI
Establishment or maintenance of cell polarity Source: UniProtKB
Exit from mitosis Source: UniProtKB
G2/M transition of mitotic cell cycle Source: Reactome
Golgi organization Source: UniProtKB
Microtubule anchoring Source: UniProtKB
Microtubule bundle formation Source: UniProtKB
Microtubule cytoskeleton organization Source: UniProtKB
Microtubule nucleation Source: UniProtKB
Microtubule organizing center organization Source: UniProtKB
Mitotic spindle assembly Source: UniProtKB
Mitotic spindle organization Source: UniProtKB
Negative regulation of microtubule depolymerization Source: UniProtKB
Negative regulation of microtubule polymerization or depolymerization Source: UniProtKB
Negative regulation of stress fiber assembly Source: UniProtKB
Negative regulation of wound healing, spreading of epidermal cells Source: UniProtKB
Positive regulation of basement membrane assembly involved in embryonic body morphogenesis Source: UniProtKB
Positive regulation of epithelial cell migration Source: UniProtKB
Positive regulation of exocytosis Source: UniProtKB
Positive regulation of extracellular matrix disassembly Source: UniProtKB
Positive regulation of microtubule polymerization Source: UniProtKB
Regulation of epithelial to mesenchymal transition Source: UniProtKB
Regulation of focal adhesion assembly Source: UniProtKB
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Regulation of gastrulation Source: UniProtKB
Regulation of microtubule cytoskeleton organization Source: UniProtKB
Vesicle targeting Source: UniProtKB

Cellular Location

Cytoskeleton; Centrosome; Spindle; Trans-Golgi network; Kinetochore. Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.