CRNN

CRNN (Cornulin) is a Protein Coding gene. Diseases associated with CRNN include Oral Squamous Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is FLG2.

Cornulin

Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832).

Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832).

Cell-cell adhesion Source: UniProtKB
Cellular response to cytokine stimulus Source: UniProtKB
Positive regulation of cell cycle G1/S phase transition Source: UniProtKB
Positive regulation of keratinocyte proliferation Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Regulation of gene expression Source: UniProtKB
Regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Response to heat Source: UniProtKB

Cytoplasm. Does not colocalize with TGM1.

Esophageal cancer (ESCR):
A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.