CYP2E1

CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Alcohol Abuse and Fatty Liver Disease. Among its related pathways are Caffeine Pathway, Pharmacokinetics and Acetaminophen Pathway (therapeutic doses), Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C9.

Cytochrome P450 Family 2 Subfamily E Member 1

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:10553002, PubMed:18577768).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10553002, PubMed:18577768).

Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed:10553002, PubMed:18577768).

May be involved in the oxidative metabolism of xenobiotics (Probable).

4-nitrophenol metabolic process Source: UniProtKB
Benzene metabolic process Source: Reactome
Carbon tetrachloride metabolic process Source: Reactome
Drug metabolic process Source: BHF-UCL
Epoxygenase P450 pathway Source: GO_Central
Exogenous drug catabolic process Source: GO_Central
Halogenated hydrocarbon metabolic process Source: Reactome
Heterocycle metabolic process Source: BHF-UCL
Lipid hydroxylation Source: UniProtKB
Long-chain fatty acid biosynthetic process Source: Reactome
Monoterpenoid metabolic process Source: BHF-UCL
Organic acid metabolic process Source: GO_Central
Response to bacterium Source: Ensembl
Response to ethanol Source: Ensembl
Response to organonitrogen compound Source: Ensembl
Response to ozone Source: Ensembl
Steroid metabolic process Source: BHF-UCL
Triglyceride metabolic process Source: Ensembl
Xenobiotic metabolic process Source: GO_Central

Endoplasmic reticulum membrane; Microsome membrane; Mitochondrion inner membrane. Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein.