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DNM1

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Full Name
Dynamin 1
Function
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
Biological Process
Dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
Endocytosis Source: BHF-UCL
Endosome organization Source: BHF-UCL
G protein-coupled receptor internalization Source: Ensembl
Membrane fusion Source: GO_Central
Mitochondrial fission Source: GO_Central
Modulation of chemical synaptic transmission Source: Ensembl
Positive regulation of synaptic vesicle endocytosis Source: Ensembl
Postsynaptic neurotransmitter receptor internalization Source: GO_Central
Receptor internalization Source: GO_Central
Receptor-mediated endocytosis Source: UniProtKB
Regulation of synapse structure or activity Source: GO_Central
Response to amyloid-beta Source: Ensembl
Synaptic vesicle budding from presynaptic endocytic zone membrane Source: GO_Central
Toxin transport Source: Ensembl
Cellular Location
Cytoskeleton; Cytoplasm. Microtubule-associated.
Involvement in disease
Developmental and epileptic encephalopathy 31 (DEE31):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent.

Anti-DNM1 antibodies

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Target: DNM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Mouse
Clone: 3D3
Application*: E, IF, WB
Target: DNM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 3G4B6
Application*: E, F, IH, C, P, WB
Target: DNM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EP801Y
Application*: IC, IF, P, WB
Target: DNM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D5
Application*: IP, F, P, WB
Target: DNM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle
Clone: Hudy 1
Application*: IC, IP, WB
Target: DNM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Dog, Mouse
Clone: 8/DLP1
Application*: WB, IF
Target: DNM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13B229
Application*: E, IH, WB
Target: DNM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Chicken, Dog, Mouse
Clone: 41/Dynamin
Application*: WB, IF, IH
Target: DNM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle
Clone: 4E67
Application*: C, IP, WB
Target: DNM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCD-355
Application*: F, IP, IH, WB
Target: DNM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle
Clone: 0.T.178
Application*: IC, IF, IP, WB
Target: DNM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3G4B6
Application*: WB, IHC
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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