ELAVL4
ELAVL4 (ELAV Like RNA Binding Protein 4) is a protein coding gene. Diseases associated with ELAVL4 include Hallucinogen Abuse and Paraneoplastic Neurologic Disorders. Gene Ontology annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ELAVL2.
Research Area
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598).
Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598).
Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:7898713, PubMed:10710437, PubMed:12034726, PubMed:12468554).
Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity).
By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726).
Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726).
Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628).
Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity).
Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity).
Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity).
Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598).
Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity).
May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657).
Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity).
Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726).
By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity).
Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity).
By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity).
Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628).
Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity).
May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity).
Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity).
Also plays a role in the regulation of alternative splicing (PubMed:17035636).
May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636).
Biological Process
3'-UTR-mediated mRNA stabilization Source: UniProtKB
Aging Source: Ensembl
Associative learning Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cerebral cortex neuron differentiation Source: Ensembl
Dendrite morphogenesis Source: Ensembl
Locomotory behavior Source: Ensembl
mRNA processing Source: ProtInc
Positive regulation of 3'-UTR-mediated mRNA stabilization Source: UniProtKB
Positive regulation of dendrite development Source: Ensembl
Regeneration Source: Ensembl
Regulation of translation at synapse, modulating synaptic transmission Source: Ensembl
Response to cocaine Source: Ensembl
Response to endoplasmic reticulum stress Source: Ensembl
RNA processing Source: UniProtKB
RNA splicing Source: UniProtKB-KW
PTM
Methylated by CARM1, which leads to reduced RNA-binding activity and enhanced interaction with SMN (PubMed:21088113). Methylation at Arg-248 by CARM1 weakens protective binding to the 3'UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (By similarity). Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity).
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Datasheet