EP400

EP400 (E1A Binding Protein P400) is a protein coding gene. Diseases associated with EP400 include Ossifying Fibromyxoid Tumor. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Chromatin organization. Gene Ontology annotations related to this gene include chromatin binding and helicase activity. An important paralog of the gene is SRCAP.

E1A binding protein p400

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.

Histone H2A acetylation Source: UniProtKB
Histone H4 acetylation Source: UniProtKB

Nucleus