GHSR

This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.

growth hormone secretagogue receptor

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

Actin polymerization or depolymerization Source: UniProtKB
Adult feeding behavior Source: HGNC-UCL
Cellular response to insulin-like growth factor stimulus Source: Ensembl
Cellular response to insulin stimulus Source: Ensembl
Cellular response to lipopolysaccharide Source: Ensembl
Cellular response to thyroid hormone stimulus Source: Ensembl
Decidualization Source: UniProtKB
Ghrelin secretion Source: Ensembl
G protein-coupled receptor signaling pathway Source: HGNC-UCL
Growth hormone secretion Source: HGNC-UCL
Hormone-mediated signaling pathway Source: HGNC-UCL
Learning or memory Source: Ensembl
Negative regulation of appetite Source: Ensembl
Negative regulation of inflammatory response Source: UniProtKB
Negative regulation of insulin secretion Source: Ensembl
Negative regulation of interleukin-1 beta production Source: UniProtKB
Negative regulation of interleukin-6 production Source: UniProtKB
Negative regulation of locomotion involved in locomotory behavior Source: Ensembl
Negative regulation of macrophage apoptotic process Source: Ensembl
Negative regulation of norepinephrine secretion Source: Ensembl
Negative regulation of tumor necrosis factor production Source: UniProtKB
Positive regulation of appetite Source: HGNC-UCL
Positive regulation of eating behavior Source: Ensembl
Positive regulation of fatty acid metabolic process Source: Ensembl
Positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
Positive regulation of multicellular organism growth Source: HGNC-UCL
Positive regulation of small intestinal transit Source: Ensembl
Positive regulation of small intestine smooth muscle contraction Source: Ensembl
Positive regulation of sprouting angiogenesis Source: Ensembl
Positive regulation of vascular endothelial cell proliferation Source: Ensembl
Postsynaptic modulation of chemical synaptic transmission Source: Ensembl
Regulation of gastric motility Source: Ensembl
Regulation of growth hormone secretion Source: Ensembl
Regulation of hindgut contraction Source: Ensembl
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Source: Ensembl
Regulation of postsynapse organization Source: Ensembl
Regulation of synapse assembly Source: Ensembl
Regulation of transmission of nerve impulse Source: Ensembl
Response to dexamethasone Source: Ensembl
Response to estradiol Source: Ensembl
Response to follicle-stimulating hormone Source: Ensembl
Response to food Source: Ensembl
Response to growth hormone Source: Ensembl
Response to hormone Source: UniProtKB
Response to monosodium glutamate Source: Ensembl
Spermatogenesis Source: Ensembl

Cell membrane

Growth hormone deficiency, isolated partial (GHDP):
A disorder characterized by partial growth hormone deficiency resulting in growth delay and short stature, sometimes associated with recurrent episodes of abdominal pain, vomiting, ketosis and hypoglycemia.

Extracellular: 1-40
Helical: 41-66
Cytoplasmic: 67-72
Helical: 73-96
Extracellular: 97-117
Helical: 118-139
Cytoplasmic: 140-162
Helical: 163-183
Extracellular: 184-211
Helical: 212-235
Cytoplasmic: 236-263
Helical: 264-285
Extracellular: 286-302
Helical: 303-326
Cytoplasmic: 327-366