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IGL

Immunoglobulins recognize foreign antigens and initiate immune responses such as the complement system and phagocytosis. Each immunoglobulin molecule is constituted by two identical heavy chains and two identical light chains. Kappa and lambda are two classes of light chains. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species.

Full Name

Immunoglobulin Lambda Locus

Anti-IGL antibodies

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Rat Anti-Igl Recombinant Antibody (CBYJL-2426) (CBMAB-L2760-YJ)

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Target: IGL

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBYJL-2426

Application*: E, C, WB

Mouse Anti-IGL Recombinant Antibody (HIglambda) (CBMAB-L0442-YJ)

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Target: IGL

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: HIglambda

Application*: F, IF

Mouse Anti-IGL Recombinant Antibody (CBYJL-1030) (CBMAB-L0441-YJ)

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Target: IGL

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1030

Application*: E, F, IH

Goat Anti-IGL Recombinant Antibody (CBYJL-1029) (CBMAB-L0440-YJ)

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Target: IGL

Host: Goat

Antibody Isotype: Ig

Specificity: Human

Clone: CBYJL-1029

Application*: E, F, IH

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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