IL23A

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

Interleukin 23 Subunit Alpha

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:BHF-UCL
Defense response to virusIEA:UniProtKB-KW
Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of activated T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of activation of Janus kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of defense response to virus by hostManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of granulocyte macrophage colony-stimulating factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of memory T cell differentiationISS:BHF-UCL
Positive regulation of natural killer cell activation1 PublicationIC:BHF-UCL
Positive regulation of natural killer cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neutrophil chemotaxisIEA:Ensembl
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of NK T cell activationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of NK T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of osteoclast differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STATIDA:ComplexPortal
Positive regulation of T cell mediated cytotoxicityISS:BHF-UCL
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T-helper 1 type immune responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T-helper 17 cell lineage commitmentISS:BHF-UCL
Positive regulation of T-helper 17 type immune responseIDA:ComplexPortal
Positive regulation of tissue remodeling1 PublicationIC:BHF-UCL
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
T cell proliferationIEA:Ensembl
Tissue remodelingIEA:UniProtKB-KW

Secreted