KAT2B

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]

Lysine Acetyltransferase 2B

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:8945521).
Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (PubMed:8945521).
Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5 (PubMed:9707565, PubMed:10675335, PubMed:23001180, PubMed:27796307, PubMed:23932781, PubMed:26867678, PubMed:29174768).
Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A (PubMed:8684459).
Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221).
Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768).
Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing (PubMed:26867678).
Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis (PubMed:23001180).
Also acetylates spermidine (PubMed:27389534).
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.

Cell cycleIEA:UniProtKB-KW
Cellular response to insulin stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Chromatin remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Epigenetic maintenance of chromatin in transcription-competent conformationTAS:Reactome
Heart developmentISS:UniProtKB
Histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Histone H3-K9 acetylationIEA:Ensembl
Internal peptidyl-lysine acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Limb developmentISS:UniProtKB
N-terminal peptidyl-lysine acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of centriole replicationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of rRNA processingManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-lysine acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of gluconeogenesisIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Protein acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Regulation of protein ADP-ribosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Rhythmic processIEA:UniProtKB-KW

Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm. Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. Subcellular location may vary depending upon cell differentiation state. Cytoplasmic at the very stages of keratinocyte differentiation, becomes nuclear at later differentiation stages. Cytoplasmic in basal epithelial cells (undifferentiated cells) and nuclear in parabasal cells (differentiated cells) (PubMed:20940255).

Defects in KAT2B has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea