NLGN2

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.

Neuroligin 2

Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity).
Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).

Brain developmentIEA:Ensembl
Cell-cell adhesion1 PublicationNAS:UniProtKB
Cell-cell junction maintenance1 PublicationNAS:UniProtKB
Chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Gephyrin clustering involved in postsynaptic density assemblyISS:BHF-UCL
Inhibitory synapse assemblyIEA:Ensembl
Insulin metabolic processIEA:Ensembl
Jump responseIEA:Ensembl
Locomotory exploration behaviorIEA:Ensembl
Modulation of chemical synaptic transmissionISS:BHF-UCL
Neuromuscular process controlling balanceIEA:Ensembl
Neuron cell-cell adhesionISS:BHF-UCL
Neurotransmitter-gated ion channel clusteringIEA:Ensembl
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of dendritic spine developmentIEA:Ensembl
Positive regulation of excitatory postsynaptic potentialISS:BHF-UCL
Positive regulation of inhibitory postsynaptic potentialISS:BHF-UCL
Positive regulation of insulin secretionManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of protein localization to synapseManual Assertion Based On ExperimentIDA:MGI
Positive regulation of synapse assemblyISS:BHF-UCL
Positive regulation of synaptic transmission, GABAergicISS:BHF-UCL
Positive regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Positive regulation of synaptic vesicle clusteringIEA:Ensembl
Positive regulation of t-SNARE clusteringIEA:Ensembl
Postsynaptic density protein 95 clusteringISS:BHF-UCL
Postsynaptic membrane assemblyISS:BHF-UCL
Presynapse assemblyManual Assertion Based On ExperimentTAS:ARUK-UCL
Presynaptic membrane assemblyISS:BHF-UCL
Protein localization to cell surfaceIEA:Ensembl
Protein localization to synapseISS:BHF-UCL
Regulation of AMPA receptor activityISS:BHF-UCL
Regulation of presynapse assemblyIEA:Ensembl
Regulation of respiratory gaseous exchange by nervous system processISS:BHF-UCL
Sensory perception of painIEA:Ensembl
Social behaviorIEA:Ensembl
Synapse assemblyISS:BHF-UCL
Synapse organizationISS:BHF-UCL
Synaptic transmission, GABAergicIEA:Ensembl
Synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Terminal button organizationISS:BHF-UCL
ThigmotaxisIEA:Ensembl

Cell membrane
Cell junction, synapse, postsynaptic cell membrane
Cell junction, synapse, presynaptic cell membrane
Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity).
Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina (By similarity).

Extracellular: 15-677
Helical: 678-698
Cytoplasmic: 699-835