RAMP3

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq]

receptor (G protein-coupled) activity modifying protein 3

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process adrenomedullin receptor signaling pathwayManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process amylin receptor signaling pathwayManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to estradiol stimulusISS:UniProtKB
Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cross-receptor inhibition within G protein-coupled receptor heterodimerManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process G protein-coupled receptor signaling pathway involved in heart processISS:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process positive regulation of calcium ion import across plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of cell deathManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of protein kinase A signalingManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of receptor recyclingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process receptor internalizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to amyloid-betaManual Assertion Based On ExperimentIGI:ARUK-UCL

Cell membrane
Membrane
Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Extracellular: 24-118
Helical: 119-138
Cytoplasmic: 139-148