RYK

RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding.

Receptor-Like Tyrosine Kinase

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Biological Process axon extension involved in axon guidanceIEA:Ensembl
Biological Process axon guidanceISS:UniProtKB
Biological Process axonogenesisISS:ParkinsonsUK-UCL
Biological Process canonical Wnt signaling pathway1 PublicationNAS:ParkinsonsUK-UCL
Biological Process cell proliferation in midbrainISS:ParkinsonsUK-UCL
Biological Process chemorepulsion of dopaminergic neuron axonISS:ParkinsonsUK-UCL
Biological Process commissural neuron axon guidanceISS:ParkinsonsUK-UCL
Biological Process corpus callosum developmentISS:UniProtKB
Biological Process midbrain dopaminergic neuron differentiationISS:ParkinsonsUK-UCL
Biological Process negative regulation of axon extension involved in axon guidanceIEA:Ensembl
Biological Process neurogenesis1 PublicationNAS:ParkinsonsUK-UCL
Biological Process neuron differentiationISS:UniProtKB
Biological Process neuron projection developmentISS:UniProtKB
Biological Process non-canonical Wnt signaling pathway1 PublicationNAS:ParkinsonsUK-UCL
Biological Process phosphorylationIEA:UniProtKB-KW
Biological Process planar cell polarity pathway involved in axon guidanceISS:ParkinsonsUK-UCL
Biological Process positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process skeletal system morphogenesisIEA:Ensembl
Biological Process synapse assembly1 PublicationNAS:ParkinsonsUK-UCL
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Wnt signaling pathway involved in midbrain dopaminergic neuron differentiationISS:ParkinsonsUK-UCL

Membrane
Nucleus
Cytoplasm
In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.

Extracellular: 26-227
Helical: 228-248
Cytoplasmic: 249-607

Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.