SFRP2

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.

Secreted Frizzled Related Protein 2

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

Biological Process BMP signaling pathwayIEA:Ensembl
Biological Process branching involved in blood vessel morphogenesisISS:BHF-UCL
Biological Process canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cardiac left ventricle morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cardiac muscle cell apoptotic processIEA:Ensembl
Biological Process cell-cell signalingISS:BHF-UCL
Biological Process cellular response to extracellular stimulusIEA:Ensembl
Biological Process cellular response to X-rayIEA:Ensembl
Biological Process chondrocyte developmentIEA:Ensembl
Biological Process collagen fibril organizationIEA:Ensembl
Biological Process convergent extension involved in axis elongationIEA:Ensembl
Biological Process digestive tract morphogenesisIEA:Ensembl
Biological Process embryonic digit morphogenesisIEA:Ensembl
Biological Process hematopoietic stem cell proliferationISS:UniProtKB
Biological Process male gonad developmentIEA:Ensembl
Biological Process mesodermal cell fate specificationIEA:Ensembl
Biological Process negative regulation of BMP signaling pathwayIEA:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cardiac muscle cell apoptotic processIEA:Ensembl
Biological Process negative regulation of cell growthManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationBy SimilarityISS:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA:Ensembl
Biological Process negative regulation of dermatome developmentISS:BHF-UCL
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of epithelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Biological Process negative regulation of gene expressionBy SimilarityISS:UniProtKB
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageISS:BHF-UCL
Biological Process negative regulation of JUN kinase activityIEA:Ensembl
Biological Process negative regulation of mesodermal cell fate specificationIEA:Ensembl
Biological Process negative regulation of peptidyl-tyrosine phosphorylationBy SimilarityISS:UniProtKB
Biological Process negative regulation of planar cell polarity pathway involved in axis elongationIEA:Ensembl
Biological Process negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process outflow tract morphogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process planar cell polarity pathway involved in axis elongationIEA:Ensembl
Biological Process planar cell polarity pathway involved in neural tube closureIEA:Ensembl
Biological Process positive regulation of angiogenesisISS:BHF-UCL
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of canonical Wnt signaling pathwayISS:BHF-UCL
Biological Process positive regulation of cell adhesion mediated by integrinISS:BHF-UCL
Biological Process positive regulation of cell growthBy SimilarityISS:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of fat cell differentiationManual Assertion Based On ExperimentIDA:MGI
Biological Process positive regulation of osteoblast differentiationIEA:Ensembl
Biological Process positive regulation of peptidyl-serine phosphorylationISS:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Biological Process post-anal tail morphogenesisIEA:Ensembl
Biological Process regulation of midbrain dopaminergic neuron differentiationIEA:Ensembl
Biological Process regulation of neuron projection developmentIEA:Ensembl
Biological Process regulation of stem cell divisionISS:UniProtKB
Biological Process response to nutrientIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sclerotome developmentISS:BHF-UCL
Biological Process stem cell fate specificationIEA:Ensembl
Biological Process Wnt signaling pathway involved in somitogenesisIEA:Ensembl

Secreted