SLC11A1

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

Solute Carrier Family 11 Member 1

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Biological Process activation of protein kinase activityISS:BHF-UCL
Biological Process antigen processing and presentation of peptide antigenISS:BHF-UCL
Biological Process antimicrobial humoral responseTAS:Reactome
Biological Process cadmium ion transmembrane transportManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process cell redox homeostasisTAS:Reactome
Biological Process cellular cadmium ion homeostasisManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process cellular iron ion homeostasisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process defense response to bacteriumISS:BHF-UCL
Biological Process defense response to Gram-negative bacteriumISS:BHF-UCL
Biological Process defense response to protozoanISS:BHF-UCL
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process inflammatory responseISS:BHF-UCL
Biological Process iron ion homeostasisISS:BHF-UCL
Biological Process iron ion transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process L-arginine transmembrane transportIEA:Ensembl
Biological Process macrophage activationISS:BHF-UCL
Biological Process manganese ion transportISS:BHF-UCL
Biological Process metal ion transportBy SimilarityISS:BHF-UCL
Biological Process MHC class II biosynthetic processISS:BHF-UCL
Biological Process mRNA stabilizationISS:BHF-UCL
Biological Process multicellular organismal iron ion homeostasisISS:BHF-UCL
Biological Process negative regulation of cytokine productionISS:BHF-UCL
Biological Process nitrite transportISS:BHF-UCL
Biological Process phagocytosisISS:BHF-UCL
Biological Process positive regulation of cytokine productionISS:BHF-UCL
Biological Process positive regulation of dendritic cell antigen processing and presentationISS:BHF-UCL
Biological Process positive regulation of gene expressionISS:BHF-UCL
Biological Process positive regulation of interferon-gamma productionISS:ARUK-UCL
Biological Process positive regulation of phagocytosisISS:BHF-UCL
Biological Process positive regulation of T-helper 1 type immune responseISS:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Biological Process respiratory burstISS:BHF-UCL
Biological Process response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to interferon-gammaISS:BHF-UCL
Biological Process response to lipopolysaccharideISS:BHF-UCL
Biological Process T cell proliferation involved in immune responseISS:BHF-UCL
Biological Process vacuolar acidificationISS:BHF-UCL
Biological Process wound healingISS:BHF-UCL

Membrane

Cytoplasmic: 1-58
Helical: 59-76
Extracellular: 77-85
Helical: 86-105
Cytoplasmic: 106-142
Helical: 143-163
Extracellular: 164-167
Helical: 168-187
Cytoplasmic: 188-196
Helical: 197-217
Extracellular: 218-240
Helical: 241-259
Cytoplasmic: 260-287
Helical: 288-307
Extracellular: 308-349
Helical: 350-369
Cytoplasmic: 370-400
Helical: 401-418
Extracellular: 419-429
Helical: 430-450
Cytoplasmic: 451-466
Helical: 467-488
Extracellular: 489-496
Helical: 497-516
Cytoplasmic: 517-550