TMED2

TMED2 (Transmembrane P24 Trafficking Protein 3) is a Protein Coding gene. Diseases related to TMED3 include Keratoconus. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. An important paralog of TMED2 is TMED7.

Full Name

Transmembrane P24 Trafficking Protein 2

Function

Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.

Biological Process

Biological Process allantois developmentSource:Ensembl
Biological Process branching involved in labyrinthine layer morphogenesisSource:Ensembl
Biological Process chorion developmentSource:Ensembl
Biological Process COPI coating of Golgi vesicleSource:UniProtKB1 Publication
Biological Process COPII vesicle coatingSource:UniProtKB1 Publication
Biological Process endoplasmic reticulum membrane organizationSource:Ensembl
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportSource:GO_Central1 Publication
Biological Process Golgi organizationSource:UniProtKB1 Publication
Biological Process heart loopingSource:Ensembl
Biological Process intracellular protein transportSource:UniProtKB1 Publication
Biological Process labyrinthine layer blood vessel developmentSource:Ensembl
Biological Process maternal placenta developmentSource:Ensembl
Biological Process multicellular organism growthSource:Ensembl
Biological Process negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylationSource:Ensembl
Biological Process negative regulation of GTPase activitySource:UniProtKB1 Publication
Biological Process neural tube closureSource:Ensembl
Biological Process PERK-mediated unfolded protein responseSource:Ensembl
Biological Process positive regulation of gene expressionSource:Ensembl
Biological Process post-anal tail morphogenesisSource:Ensembl
Biological Process protein localization to plasma membraneSource:UniProtKB1 Publication
Biological Process regulation of SREBP signaling pathwaySource:Ensembl
Biological Process somite rostral/caudal axis specificationSource:Ensembl
Biological Process vesicle cargo loadingSource:UniProtKB1 Publication

Cellular Location

Cytoplasmic vesicle membrane
Cytoplasmic vesicle, COPI-coated vesicle membrane
Golgi apparatus, cis-Golgi network membrane
Golgi apparatus, Golgi stack membrane
Endoplasmic reticulum membrane
Endoplasmic reticulum-Golgi intermediate compartment membrane
Cycles between compartments of the early secretatory pathway.

Topology

Lumenal: 21-168
Helical: 169-189
Cytoplasmic: 190-201