TSPAN32

This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]

Full Name

tetraspanin 32

Biological Process

Biological Process cell-cell signaling Source:UniProtKB1 Publication
Biological Process cytoskeleton organization Source:Ensembl
Biological Process defense response to protozoan Source:Ensembl
Biological Process integrin-mediated signaling pathway Source:Ensembl
Biological Process negative regulation of myeloid dendritic cell activation Source:Ensembl
Biological Process negative regulation of T cell proliferation Source:Ensembl
Biological Process platelet aggregation Source:Ensembl
Biological Process protein localization to plasma membrane Source:GO_Central1 Publication
Biological Process protein maturation Source:GO_Central1 Publication
Biological Process regulation of defense response to virus Source:Ensembl
Biological Process T cell proliferation Source:Ensembl

Cellular Location

Membrane