UCN

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]

Urocortin

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563).
Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563).
Plays a role in the establishment of normal hearing thresholds (By similarity).
Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).

Biological Process activation of protein kinase A activity Source:Ensembl
Biological Process aerobic respiration Source:Ensembl
Biological Process associative learning Source:Ensembl
Biological Process drinking behavior Source:Ensembl
Biological Process female pregnancy Source:Ensembl
Biological Process G protein-coupled receptor signaling pathway Source:ProtInc1 Publication
Biological Process gastric emptying Source:Ensembl
Biological Process inflammatory response Source:Ensembl
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process negative regulation of appetite Source:Ensembl
Biological Process negative regulation of blood pressure Source:Ensembl
Biological Process negative regulation of cell size Source:Ensembl
Biological Process negative regulation of feeding behavior Source:GO_Central1 Publication
Biological Process negative regulation of gastric acid secretion Source:Ensembl
Biological Process negative regulation of gene expression Source:Ensembl
Biological Process negative regulation of hormone secretion Source:Ensembl
Biological Process negative regulation of necrotic cell death Source:Ensembl
Biological Process negative regulation of neuron death Source:Ensembl
Biological Process neuron projection development Source:Ensembl
Biological Process neuropeptide signaling pathway Source:Ensembl
Biological Process pancreatic juice secretion Source:Ensembl
Biological Process positive regulation of behavioral fear response Source:Ensembl
Biological Process positive regulation of calcium ion import Source:Ensembl
Biological Process positive regulation of cAMP-mediated signaling Source:Ensembl
Biological Process positive regulation of cardiac muscle contraction Source:Ensembl
Biological Process positive regulation of cell growth Source:Ensembl
Biological Process positive regulation of collagen biosynthetic process Source:Ensembl
Biological Process positive regulation of corticotropin secretion Source:UniProtKB1 Publication
Biological Process positive regulation of DNA replication Source:Ensembl
Biological Process positive regulation of interleukin-6 production Source:Ensembl
Biological Process positive regulation of peptidyl-serine phosphorylation Source:Ensembl
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process positive regulation of translation Source:Ensembl
Biological Process positive regulation of vascular permeability Source:Ensembl
Biological Process regulation of synaptic transmission, glutamatergic Source:Ensembl
Biological Process response to auditory stimulus Source:Ensembl
Biological Process response to estradiol Source:Ensembl
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to oxidative stress Source:Ensembl
Biological Process response to pain Source:Ensembl
Biological Process sensory perception of sound Source:UniProtKB-KW
Biological Process social behavior Source:Ensembl
Biological Process startle response Source:Ensembl
Biological Process vasodilation Source:Ensembl

Secreted