WNT7A

WNT7A is a protein-coding gene which is a member of the WNT gene family consists of structurally related genes that encode secreted signaling proteins. Diseases associated with WNT7A include Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly and Ulna And Fibula, Absence Of, With Severe Limb Deficiency. An important paralog of this gene is WNT7B.

Wnt family member 7A

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).
Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533).
Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314).
Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity).
Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity).
Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity).
Promotes formation of synapses via its interaction with FZD5 (By similarity).

Biological Process angiogenesis Source:Ensembl
Biological Process apoptotic process Source:Ensembl
Biological Process asymmetric protein localization involved in cell fate determination Source:Ensembl
Biological Process axonogenesis Source:ParkinsonsUK-UCL1 Publication
Biological Process canonical Wnt signaling pathway Source:BHF-UCL5 Publications
Biological Process cartilage condensation Source:AgBase1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cell proliferation in forebrain Source:BHF-UCL1 Publication
Biological Process cellular response to transforming growth factor beta stimulus Source:UniProtKB1 Publication
Biological Process central nervous system vasculogenesis Source:Ensembl
Biological Process cerebellar granule cell differentiation Source:Ensembl
Biological Process chondrocyte differentiation Source:AgBase1 Publication
Biological Process dendritic spine morphogenesis Source:ParkinsonsUK-UCL1 Publication
Biological Process dorsal/ventral pattern formation Source:Ensembl
Biological Process embryonic axis specification Source:BHF-UCL1 Publication
Biological Process embryonic digit morphogenesis Source:BHF-UCL1 Publication
Biological Process embryonic forelimb morphogenesis Source:BHF-UCL1 Publication
Biological Process embryonic hindlimb morphogenesis Source:BHF-UCL1 Publication
Biological Process establishment of cell polarity Source:Ensembl
Biological Process excitatory synapse assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process lens fiber cell development Source:BHF-UCLBy Similarity
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process negative regulation of neurogenesis Source:BHF-UCL1 Publication
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process neurotransmitter secretion Source:Ensembl
Biological Process oviduct development Source:Ensembl
Biological Process positive regulation of DNA-templated transcription Source:BHF-UCL1 Publication
Biological Process positive regulation of endothelial cell migration Source:Ensembl
Biological Process positive regulation of epithelial cell proliferation involved in wound healing Source:BHF-UCL1 Publication
Biological Process positive regulation of excitatory postsynaptic potential Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of excitatory synapse assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of gene expression Source:Ensembl
Biological Process positive regulation of JNK cascade Source:GO_Central1 Publication
Biological Process positive regulation of protein localization to presynapse Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of protein metabolic process Source:ARUK-UCL1 Publication
Biological Process positive regulation of synapse assembly Source:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process postsynapse assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process presynapse assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process regulation of axon diameter Source:Ensembl
Biological Process regulation of postsynapse organization Source:Ensembl
Biological Process regulation of presynapse assembly Source:SynGO2 Publications
Biological Process regulation of synaptic vesicle exocytosis Source:Ensembl
Biological Process response to estradiol Source:Ensembl
Biological Process response to estrogen Source:Ensembl
Biological Process secondary palate development Source:BHF-UCL1 Publication
Biological Process sex differentiation Source:ProtInc1 Publication
Biological Process skeletal muscle satellite cell activation Source:Ensembl
Biological Process skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source:Ensembl
Biological Process somatic stem cell division Source:Ensembl
Biological Process somatic stem cell population maintenance Source:Ensembl
Biological Process stem cell development Source:BHF-UCL1 Publication
Biological Process synaptic vesicle recycling Source:ParkinsonsUK-UCL1 Publication
Biological Process uterus morphogenesis Source:Ensembl
Biological Process Wnt signaling pathway, planar cell polarity pathway Source:BHF-UCL1 Publication
Biological Process wound healing, spreading of epidermal cells Source:BHF-UCL1 Publication

Secreted, extracellular space, extracellular matrix
Secreted

Limb pelvis hypoplasia aplasia syndrome (LPHAS):
A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present.
Fuhrmann syndrome (FUHRS):
Distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia.

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.