ACOD1

Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

Full Name

Aconitate Decarboxylase 1

Function

Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity).

Biological Process

Cellular response to interferon-beta
Cellular response to interferon-gamma
Cellular response to interleukin-1
Cellular response to lipopolysaccharide
Cellular response to molecule of bacterial origin
Cellular response to progesterone stimulus
Cellular response to tumor necrosis factor
Defense response
Defense response to virus
Embryo implantation
Inflammatory response
Negative regulation of inflammatory response
Negative regulation of innate immune response
Negative regulation of NF-kappaB transcription factor activity
Negative regulation of toll-like receptor 2 signaling pathway
Negative regulation of toll-like receptor 4 signaling pathway
Negative regulation of type I interferon production
Positive regulation of antimicrobial humoral response
Positive regulation of reactive oxygen species metabolic process
Tolerance induction to lipopolysaccharide

Cellular Location

Mitochondrion