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Rabbit Anti-ACOD1 Recombinant Antibody (V2-621656) (CBMAB-CP1221-LY)

The product is antibody recognizes ACOD1. The antibody D6H2Y immunoassay techniques such as: WB,IP.
See all ACOD1 antibodies
Published Data
Rabbit Anti-ACOD1 Recombinant Antibody (D6H2Y) (CBMAB-CP1221-LY) in WB
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Fischer, N. L., Boyer, M. A., Bradley, W. P., Spruce, L. A., Fazelinia, H., & Shin, S. (2022). A Coxiella burnetii effector interacts with the host PAF1 complex and suppresses the innate immune response. bioRxiv, 2022-04.

Summary

Host Animal
Rabbit
Specificity
Human
Clone
V2-621656
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly460 of human IRG1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IP1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Aconitate Decarboxylase 1
Introduction
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
Entrez Gene ID
730249
UniProt ID
A6NK06
Alternative Names
Aconitate Decarboxylase 1; Cis-Aconitic Acid Decarboxylase; IRG1; CAD; Immune-Responsive Gene 1 Protein Homolog; Immunoresponsive 1 Homolog (Mouse);
Function
Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity).
Biological Process
Cellular response to interferon-beta
Cellular response to interferon-gamma
Cellular response to interleukin-1
Cellular response to lipopolysaccharide
Cellular response to molecule of bacterial origin
Cellular response to progesterone stimulus
Cellular response to tumor necrosis factor
Defense response
Defense response to virus
Embryo implantation
Inflammatory response
Negative regulation of inflammatory response
Negative regulation of innate immune response
Negative regulation of NF-kappaB transcription factor activity
Negative regulation of toll-like receptor 2 signaling pathway
Negative regulation of toll-like receptor 4 signaling pathway
Negative regulation of type I interferon production
Positive regulation of antimicrobial humoral response
Positive regulation of reactive oxygen species metabolic process
Tolerance induction to lipopolysaccharide
Cellular Location
Mitochondrion
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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