Signal Transduction Research

The process of signal transduction constitutes a central paradigm in cellular communication, through which cells interpret and respond to stimuli from the extracellular environment via highly specific molecular interactions. This dynamic process involves a cascade of biochemical events initiated by ligand-receptor binding, leading to intracellular effector activation and downstream physiological responses. By converting external signals—such as hormones, growth factors, or environmental stressors—into intracellular actions, signaling networks regulate critical functions, including cell proliferation, differentiation, survival, and apoptosis. These pathways are tightly controlled by post-translational modifications (e.g., phosphorylation), second messengers (e.g., cAMP, calcium ions), and effector proteins to ensure specificity and adaptability.

Key pathways, such as mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/AKT, and Janus kinase-signal transducer and activator of transcription (JAK-STAT), exemplify the complexity of signal transduction. The initial perception of extracellular stimuli is predominantly mediated by transmembrane receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). These integral membrane proteins function as the primary sensors, and their ligand-induced activation triggers intracellular signaling cascades through the engagement of adaptor proteins, kinases, and ultimately, transcription factors. Cross-talk between pathways further amplifies regulatory precision, enabling cells to integrate diverse inputs and generate context-dependent outcomes.

Dysregulated signaling is a hallmark of numerous diseases, such as cancer, autoimmune disorders, and neurodegenerative conditions. For instance, hyperactivation of oncogenic kinases or mutations in tumor suppressor genes can drive uncontrolled cell growth. Similarly, aberrant immune signaling underpins chronic inflammation and autoimmunity. Identifying molecular hubs within these pathways (such as kinases, phosphatases, or transcription factors) offers opportunities for targeted therapeutic interventions aimed at restoring signaling equilibrium.

Creative Biolabs provides rigorously validated antibodies essential for dissecting signaling pathways. The available portfolio comprises a suite of antibodies directed against key signaling molecules, including phosphorylated epitopes, cell-surface receptors, and various downstream effectors. These reagents are specifically validated for robust performance in critical applications such as flow cytometry, immunofluorescence, and multiplexed immunoassays. Each reagent undergoes stringent validation to ensure batch-to-batch consistency, enabling researchers to map signaling dynamics with confidence and accelerate discoveries in disease mechanisms and drug development.

Product List

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Target: CSK
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXC-3040
Application*: WB, IF
Target: PIK3R1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: EC215
Application*: WB, P
Target: GPR25
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1398
Application*: WB: 1:500~1:1000 ELISA: 1:1000
Target: GPR152
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1384
Application*: IF: 1:100~1:500 ELISA: 1:1000
Target: GPR146
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1380
Application*: WB: 1:500~1:1000 ELISA: 1:5000
Target: GPR107
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1358
Application*: WB: 1:500~1:1000 ELISA: 1:1000
Target: DGKA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG951
Application*: IP, F, WB
Target: KPNA2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: A780
Application*: ICC, IHC, IP, WB
Target: KIF7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A761
Application*: ELISA, IHC
Target: KCNC2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A733
Application*: ICC/IF, IHC, WB
Target: INS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Human
Clone: A641
Application*: FC, IF, IHC
Target: INS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Human, Pig
Clone: A633
Application*: ELISA
Target: IGF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: A426
Application*: FC, IF, Neutralizing
Target: ICAM3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A366
Application*: ELISA, FC, IF, IHC, IP, RIA, WB
Target: HVCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A344
Application*: ELISA, IHC, WB
Target: HTN1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: A343
Application*: ICC, IHC, IP, WB
Target: HSPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Bacteria, Cattle, Chicken, Dog, Fish, Guinea pig, Hamster, Human, Insect, Monkey, Mouse, Pig, Plant, Rabbit, Rat
Clone: A333
Application*: FC, IHC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A323
Application*: IHC, WB
Target: HSPB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: A319
Application*: ICC, WB
Target: HSPA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A297
Application*: ELISA, IF, IHC, WB
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For Research Use Only. Not For Clinical Use.
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