Immunology Research
Immunology explores the molecular and cellular networks that enable organisms to distinguish self from non-self, neutralize pathogens, and maintain tissue homeostasis. The immune system comprises innate and adaptive branches, each with specialized roles. Innate immunity provides immediate, nonspecific defense via phagocytes, complement proteins, and cytokines, while adaptive immunity delivers antigen-specific responses mediated by T and B lymphocytes. Central to this duality is antigen presentation, wherein dendritic cells process and display foreign peptides to activate T cells, initiating targeted effector functions such as antibody production or cytotoxic killing.
When immune regulation fails, pathologies emerge. Autoimmune disorders arise from aberrant self-antigen recognition, as seen in rheumatoid arthritis or lupus. Allergic hypersensitivity involves excessive IgE-mediated responses to innocuous antigens, while immunodeficiencies compromise host defense, increasing susceptibility to infections. Chronic inflammation, driven by unresolved immune activation, underpins conditions like inflammatory bowel disease and atherosclerosis. Key molecular mediators—cytokines (e.g., IL-6, TNF-α), chemokines, and immune checkpoints (e.g., PD-1, CTLA-4)—orchestrate these processes, making them pivotal therapeutic targets.
Advancing immunology research hinges on dissecting signaling pathways and cellular interactions at high resolution. Technologies such as single-cell sequencing has illuminated mechanisms of immune evasion in cancer and infection. Novel modalities like monoclonal antibodies, CAR-T cells, and checkpoint inhibitors exemplify translational successes derived from foundational discoveries.
Creative Biolabs provides rigorously validated antibody reagents tailored for immunological research. Our portfolio includes antibodies targeting cytokines, immune cell markers, and signaling proteins, optimized for flow cytometry, immunohistochemistry, and functional assays. Each product undergoes stringent specificity and reproducibility testing to ensure reliability in deciphering immune mechanisms. By delivering precision tools, we empower researchers to accelerate breakthroughs in understanding and modulating immune responses.
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Target: PIK3R1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: EC215
Application*: WB, P
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Target: CD226
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG14
Application*: F, In Vivo
In Vivo Assay
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Target: CD19
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG07
Application*: B, F, C, IP, WB
Functional Assay
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Target: PDCD1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG144
Application*: B, IH, In Vivo, WB
In Vivo Assay
Functional Assay
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Target: ITGA4
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AG116
Application*: F, IH, In Vivo, IP
In Vivo Assay
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Target: IFNGR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AG93
Application*: F
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Target: HPN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AG84
Application*: E, F
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Target: EGFR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AG64
Application*: IH, WB
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Target: CD47
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AG34
Application*: F, In Vivo, N
In Vivo Assay
Functional Assay
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Target: CD40
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AG31
Application*: F
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Target: CD38
Host: Mouse
Antibody Isotype: IgG1
Specificity: Monkey
Clone: AG25
Application*: F
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Target: TFRC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AG173
Application*: F, IH, In Vivo
In Vivo Assay
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Target: CD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: AG10
Application*: F, IH, WB
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Target: IL21R
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AG105
Application*: B, F, In Vivo, IP
In Vivo Assay
Functional Assay
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Target: CD19
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AG06
Application*: E, F, In Vivo
In Vivo Assay
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Target: MHC Class I
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: AG138
Application*: F, WB
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Target: MHC Class I
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AG137
Application*: IC, IP, WB
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Target: H-2Db
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG76
Application*: In Vivo, IP
In Vivo Assay
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Target: CD90.2
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AG48
Application*: MC, F, C, WB
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Target: THY1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AG176
Application*: F, WB
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For Research Use Only. Not For Clinical Use.