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Target & Antigen Products

Fig.1 (Creative Biolabs Authorized)

In the critical phases of drug discovery, structural biology, and biotherapeutic development, the structural fidelity and biological activity of recombinant target proteins are absolute prerequisites for success. Target antigens serve as the foundational reagents for high-throughput screening (HTS), phage display biopanning, and the rigorous validation of novel therapeutic modalities.

Creative Biolabs specializes in the design, expression, and extensive biophysical characterization of premium targets and antigens. By deploying advanced expression algorithms and specialized host cell platforms, we ensure the complete preservation of native three-dimensional conformations and essential post-translational modifications (PTMs). From complex multi-pass transmembrane receptors to highly glycosylated viral envelope proteins, our recombinant proteins are meticulously optimized to serve as highly efficacious immunogens and robust reagents for critical downstream assays, including IHC, IF, WB, ELISA, etc. By supplying these high-fidelity targets, we empower researchers to achieve superior specificity and consistent results across all their immunization and detection workflows.

Why Choose Creative Biolabs' Targets and Antigens?

Native Conformational Fidelity

Proprietary folding algorithms and optimal expression host selection ensure that recombinant proteins maintain their exact spatial epitopes, mimicking endogenous thermodynamic binding properties and enzymatic activities.

High Purity Profiles

Orthogonal purification strategies—combining affinity, ion-exchange, and size-exclusion chromatography—routinely achieve monomeric purity levels exceeding 90%, explicitly verified through rigorous SEC-HPLC and intact mass spectrometry.

Versatile Tagging and Labeling

We offer diverse fusion tags and precise labeling like site-specific biotinylation to seamlessly integrate into your workflows. This versatility enhances detection in assays like ELISA, IF, and WB, and maximizes immunogenicity for antibody generation.

Batch-to-Batch Consistency

Strict quality management systems and comprehensive analytical characterization protocols guarantee unwavering lot-to-lot reproducibility, securing the integrity of longitudinal screening campaigns and structural biology programs.

Expression Systems for Complex Targets

No single host environment can satisfy the diverse biochemical requirements of the entire proteome. Creative Biolabs utilizes a comprehensive suite of advanced expression platforms optimized for specific target classes.

High-Density Mammalian Expression (HEK293 & CHO)

The indispensable platform for human target proteins requiring complex, human-like post-translational modifications. This system ensures authentic N-linked and O-linked glycosylation profiling, proper disulfide bond formation, and accurate proteolytic cleavage, which are critical for the functionality of secretomes, immune checkpoint modulators, and viral glycoproteins.

Baculovirus-Insect Cell Expression (Sf9/Sf21 & Hi-5)

Optimized for the scalable production of complex intracellular signaling molecules and kinases. This platform facilitates efficient folding of large molecular weight targets while maintaining essential intracellular processing mechanisms, providing excellent yields of highly active enzymes and structural assemblies.

Microbial Expression (E. coli & Yeast)

Engineered for the rapid and highly scalable generation of structurally straightforward antigens, cytokines, and defined protein domains. Utilizing specialized chaperone-co-expression vectors, this system circumvents inclusion body formation to deliver soluble, highly purified antigens ideal for structural elucidation and baseline immunization strategies.

Ancillary Services and Support

Conjugation Services: We provide precise and reliable conjugation of antibodies and antigens with a wide array of labels (including fluorophores, biotin, and key enzymes) tailored to enhance signal detection and seamlessly fit your specific experimental setups.
Immunoassay Services: To fully support your research pipeline, we offer expert assay execution and validation services. Utilizing our premium reagents, our experienced team performs comprehensive downstream testing, such as IHC, IF, WB, ELISA, etc., delivering robust and actionable data directly to your projects.

Ready to elevate the quality of your experimental data? Creative Biolabs' technical experts are available to provide personalized project consultations and product quotes.

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Human Recombinant TNFRSF17 protein, ECD, Strep II Tag (V2LY-0526-LY2325)

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Target: TNFRSF17

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-54

Tag: Strep II Tag