Epigenetics Research
For an extended period, the central dogma positioned the DNA sequence as the definitive repository of biological information. This paradigm, however, has been profoundly expanded by the emergence of epigenetics, a field elucidating a complex super-genomic regulatory network that governs the interpretation of the genetic blueprint itself. Fundamentally, epigenetics refers to heritable alterations in gene expression, transmitted through mitosis and in some cases meiosis, that occur without modifications to the primary DNA sequence. The orchestration of gene expression through these mechanisms is now understood to be indispensable for fundamental processes, including the establishment of cellular identity during differentiation, organismal development, and the dynamic response of an organism to its environment.
The molecular basis of epigenetic regulation involves several interconnected mechanisms. Key among these are the covalent methylation of DNA, a canonical silencing mark, and a vast repertoire of post-translational modifications (PTMs) to histone proteins. These PTMs, notably acetylation and methylation, dynamically alter chromatin architecture. For instance, acetylation typically yields a relaxed, transcriptionally permissive euchromatic state, whereas specific methylation marks like H3K9me3 and H3K27me3 promote the formation of compact, inert heterochromatin. The combinatorial interplay of these modifications, influenced by non-coding RNAs, is speculated to form a sophisticated 'epigenetic code,' enabling a highly nuanced regulatory framework.
Understanding epigenetic pathways has transcended academic pursuit to become a critical frontier in disease research. A growing body of evidence now implicates dysregulated epigenetic landscapes as a central pathological feature in a wide spectrum of human diseases. This includes various malignancies and a range of neurodegenerative and metabolic disorders, where aberrant epigenetic marks are now considered critical hallmarks. To empower your research, Creative Biolabs offers a comprehensive portfolio of highly validated antibodies targeting key epigenetic players, including specific histone modifications and DNA methyltransferases. Let us provide the precise tools you need to decipher the epigenetic code and unlock new therapeutic possibilities.
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Target: HES6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1504
Application*: WB: 1:500~1:1000 ELISA: 1:10000
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Target: GCFC2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1298
Application*: WB: 1:500~1:1000 ELISA: 1:20000
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Target: IRF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A654
Application*: FC, ICC, IF, IHC, WB
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Target: HNRNPK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human, Mouse, Rabbit, Rat
Clone: A254
Application*: IHC, WB
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Target: NOTCH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A1387
Application*: FC, ICC, IF, IHC, WB
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Target: MET
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1069
Application*: IF, IHC, WB
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Target: MCRS1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: A1052
Application*: ELISA, WB
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Target: FOXM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP787
Application*: IF, IP, WB
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Target: AGO2
Host: Mouse
Antibody Isotype: IgA
Specificity: Human, Mouse, Rat
Clone: V2-634169
Application*: IF, IP, WB, E
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Target: SNRPD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CF404
Application*: ELISA, WB
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Target: RNH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF372
Application*: ELISA, WB
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Target: EEF1D
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: CF143
Application*: WB, IP, IF, E
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Target: TP63 (Dako Omnis)
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CB340
Application*: IVD
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Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB270A
Application*: ELISA, IHC
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Target: FOXP3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB69A
Application*: ELISA, WB, ICC
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Target: BRAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB71A
Application*: WB
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Target: AMACR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CB34A
Application*: WB, IP, IF, E
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Target: MSH2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 1B3=3A2B8C
Application*: WB, IHC, IF
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Target: AMACR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB012
Application*: IHC
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Target: SMAD4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse
Clone: RM277
Application*: IHC, WB
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For Research Use Only. Not For Clinical Use.