Apoptosis & Cell Viability Research
Apoptosis, a highly orchestrated form of programmed cell death, is critical for maintaining tissue homeostasis, eliminating damaged cells, and ensuring proper development. This process is governed by intrinsic (mitochondrial) and extrinsic (death receptor) pathways, both converging on caspase activation to execute controlled cellular dismantling. Conversely, cell viability assays quantify the proportion of healthy, metabolically active cells within a population, reflecting the balance between survival signals (e.g., growth factors) and stressors (e.g., oxidative damage or chemotherapeutic agents). Dysregulation of apoptotic pathways is implicated in pathologies ranging from cancer (evasion of cell death) to neurodegenerative disorders (excessive apoptosis), underscoring the need for precise molecular tools to study these processes.
In cancer research, apoptotic resistance driven by BCL-2 family protein overexpression or caspase inhibition remains a therapeutic challenge. Conversely, neurodegenerative diseases such as Alzheimer's exhibit hyperactivated apoptosis due to disrupted mitochondrial integrity. Cell viability assays, including ATP-based luminescence or membrane permeability tests, enable researchers to evaluate drug efficacy, cytotoxicity, and metabolic adaptations in real time. Advanced techniques like flow cytometry further distinguish apoptotic subpopulations via Annexin V/propidium iodide staining, while fluorescence-based caspase activity assays provide dynamic insights into apoptotic progression.
Creative Biolabs delivers rigorously validated antibody products targeting key apoptosis and cell viability markers, including cleaved caspases, BAX, BCL-2, PARP, and phosphorylated survival signaling proteins. Our antibodies demonstrate exceptional specificity in Western blotting, immunofluorescence, and flow cytometry, ensuring reliable detection across experimental models. Trusted by global researchers, these tools empower precise dissection of apoptotic mechanisms and therapeutic discovery, accelerating breakthroughs in oncology, immunology, and regenerative medicine.
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Target: MAP3K7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B9
Application*: WB, M
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Target: FAIM2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2C2
Application*: E, WB, IF
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Target: FAM3B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E7
Application*: WB, E, IP, IH
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Target: FAM3B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-1721
Application*: WB
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Target: FAM3B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2564
Application*: WB, IP, IF, E, P
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Target: FAIM2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-0270
Application*: WB, IP, IF, E
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Target: FAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1220
Application*: E, WB
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Target: FADD
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 0085
Application*: WB, IF, F
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Target: EPC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0933
Application*: WB, IP, IF, P, E
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Target: EPB41L3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: C3401
Application*: WB, IP, IF, E
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Target: EPB41L3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0229
Application*: WB, IP, IF, E
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Target: ELMO2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E5
Application*: E
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Target: ELMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: CBFYE-0793
Application*: WB, IP, IF, E
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Target: ELMO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CP0579
Application*: WB, IP, IF, E
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Target: ELMO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBFYE-0139
Application*: WB, IP, P
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Target: TNFRSF12A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4239
Application*: F
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Target: CASP3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC93
Application*: P
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Target: CASP3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC92
Application*: P
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Target: GRK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1445
Application*: WB: 1:500~1:1000 ELISA: 1:20000
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Target: MAPK8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A727
Application*: IF, WB
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For Research Use Only. Not For Clinical Use.