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Mouse Anti-BCL2L1 Recombinant Antibody (H5) (CBMAB-1025CQ)
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Mouse Anti-AMACR Recombinant Antibody (CB34A) (CBMAB-CA034LY)
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Mouse Anti-A2M Recombinant Antibody (V2-178822) (CBMAB-A0036-YC)
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Mouse Anti-BIRC3 Recombinant Antibody (16E63) (CBMAB-C3367-LY)
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Mouse Anti-ELAVL4 Recombinant Antibody (6B9) (CBMAB-1132-YC)
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Mouse Anti-ARIH1 Recombinant Antibody (C-7) (CBMAB-A3563-YC)
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Rat Anti-EMCN Recombinant Antibody (28) (CBMAB-E0280-FY)
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Mouse Anti-Acetyl-α-Tubulin (Lys40) Recombinant Antibody (V2-623485) (CBMAB-CP2897-LY)
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Mouse Anti-8-oxoguanine Recombinant Antibody (V2-7697) (CBMAB-1869CQ)
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Mouse Anti-CAPZB Recombinant Antibody (CBYY-C0944) (CBMAB-C2381-YY)
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Mouse Anti-COL12A1 Recombinant Antibody (CBYY-C3117) (CBMAB-C4560-YY)
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Rat Anti-CCR2 Recombinant Antibody (475301) (CBMAB-C1338-LY)
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Mouse Anti-BAX Recombinant Antibody (CBYY-0216) (CBMAB-0217-YY)
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Mouse Anti-BIRC3 Recombinant Antibody (315304) (CBMAB-1214-CN)
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Mouse Anti-BAD (Phospho-Ser136) Recombinant Antibody (CBYY-0138) (CBMAB-0139-YY)
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Mouse Anti-AGO2 Recombinant Antibody (V2-634169) (CBMAB-AP203LY)
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Mouse Anti-DMPK Recombinant Antibody (CBYCD-324) (CBMAB-D1200-YC)
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Rabbit Anti-ADRA1A Recombinant Antibody (V2-12532) (CBMAB-1022-CN)
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Mouse Anti-ADGRE2 Recombinant Antibody (V2-261270) (CBMAB-C0813-LY)
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Mouse Anti-C4B Recombinant Antibody (CBYY-C2996) (CBMAB-C4439-YY)
Ubiquitin Proteosome Research
The ubiquitin-proteasome system (UPS) is a highly conserved cellular machinery essential for maintaining proteostasis, regulating protein turnover, and modulating critical biological processes. Central to this system is ubiquitin, a small regulatory protein that tags substrate proteins via covalent attachment. This ubiquitination marks target proteins for degradation by the 26S proteasome, a multi-subunit protease complex. Beyond protein destruction, ubiquitination also governs non-proteolytic functions, including DNA repair, signal transduction, and immune responses, underscoring its versatility in cellular regulation.
The 26S proteasome comprises a cylindrical 20S core particle flanked by regulatory 19S particles. The 20S core houses proteolytic active sites that hydrolyze ubiquitinated substrates into short peptides, while the 19S caps recognize ubiquitin tags, unwind substrates, and translocate them into the core. Specificity is ensured by ubiquitin ligases, which confer substrate selectivity, and deubiquitinating enzymes, which recycle ubiquitin. This orchestrated process tightly controls protein quality, eliminates misfolded or damaged proteins, and adjusts cellular protein levels in response to stress or signaling cues.
UPS dysfunction is implicated in diverse pathologies. Impaired proteasomal activity contributes to neurodegenerative disorders via toxic protein aggregate accumulation, while overactivation is linked to cancer through unchecked degradation of tumor suppressors. Targeting UPS components, such as proteasome inhibitors, has emerged as a therapeutic strategy for malignancies like multiple myeloma, highlighting its clinical relevance. Understanding UPS dynamics thus remains pivotal for elucidating disease mechanisms and identifying novel interventions.
To explore UPS complexity, high-specificity antibodies are indispensable. Creative Biolabs' portfolio includes rigorously validated antibodies targeting ubiquitin, proteasome subunits, and associated enzymes, optimized for applications including western blotting, immunoprecipitation, and immunofluorescence. These tools empower precise investigation of ubiquitination dynamics, proteasome activity, and disease-associated UPS alterations, supporting researchers in advancing discoveries across molecular and translational studies.
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