AGTR1

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

Angiotensin II Receptor Type 1

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Angiotensin-activated signaling pathway
Blood vessel diameter maintenance
Calcium-mediated signaling
Cell chemotaxis
G protein-coupled receptor signaling pathway
Inflammatory response
Kidney development
Low-density lipoprotein particle remodeling
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
Phospholipase C-activating angiotensin-activated signaling pathway
Phospholipase C-activating G protein-coupled receptor signaling pathway
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Positive regulation of cellular protein metabolic process
Positive regulation of cholesterol esterification
Positive regulation of cytosolic calcium ion concentration
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Positive regulation of inflammatory response
Positive regulation of macrophage derived foam cell differentiation
Positive regulation of NAD(P)H oxidase activity
Positive regulation of phospholipase A2 activity
Positive regulation of reactive oxygen species metabolic process
Regulation of cell growth
Regulation of cell population proliferation
Regulation of inflammatory response
Regulation of renal sodium excretion
Regulation of systemic arterial blood pressure by renin-angiotensin
Regulation of vasoconstriction
Renin-angiotensin regulation of aldosterone production
Rho protein signal transduction

Cell membrane

Renal tubular dysgenesis (RTD): Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).

Extracellular: 1-27 aa
Helical: 28-52 aa
Cytoplasmic: 53-64 aa
Helical: 65-87 aa
Extracellular: 88-102 aa
Helical: 103-124 aa
Cytoplasmic: 125-142 aa
Helical: 143-162 aa
Extracellular: 163-192 aa
Helical: 193-214 aa
Cytoplasmic: 215-240 aa
Helical: 241-262 aa
Extracellular: 263-275 aa
Helical: 276-296 aa
Cytoplasmic: 297-359 aa

C-terminal Ser or Thr residues may be phosphorylated.