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Rabbit Anti-AGTR1 Recombinant Antibody (V2-180248) (CBMAB-A1681-YC)

Provided herein is a Rabbit monoclonal antibody against Human Angiotensin II Receptor Type 1. The antibody can be used for immunoassay techniques, such as WB.
See all AGTR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
V2-180248
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AGTR-1.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
50 mM Tris-glycine, pH 7.4, 150 mM sodium chloride, 40% glycerol, 0.01% sodium azide and 0.05% BSA
Buffer
PBS, pH7.3, 0.05% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Angiotensin II Receptor Type 1
Introduction
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene enc
Entrez Gene ID
Human185
Mouse11607
Rat116895565
UniProt ID
HumanP30556
MouseP29754
RatP25095
Alternative Names
Angiotensin II Receptor Type 1; AGTR1B; AT1AR; AT1BR; AT2R1; AT1; Type-1B Angiotensin II Receptor; Type-1 Angiotensin II Receptor; Angiotensin II Type-1 Receptor;
Function
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Biological Process
Angiotensin-activated signaling pathway
Blood vessel diameter maintenance
Calcium-mediated signaling
Cell chemotaxis
G protein-coupled receptor signaling pathway
Inflammatory response
Kidney development
Low-density lipoprotein particle remodeling
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
Phospholipase C-activating angiotensin-activated signaling pathway
Phospholipase C-activating G protein-coupled receptor signaling pathway
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Positive regulation of cellular protein metabolic process
Positive regulation of cholesterol esterification
Positive regulation of cytosolic calcium ion concentration
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Positive regulation of inflammatory response
Positive regulation of macrophage derived foam cell differentiation
Positive regulation of NAD(P)H oxidase activity
Positive regulation of phospholipase A2 activity
Positive regulation of reactive oxygen species metabolic process
Regulation of cell growth
Regulation of cell population proliferation
Regulation of inflammatory response
Regulation of renal sodium excretion
Regulation of systemic arterial blood pressure by renin-angiotensin
Regulation of vasoconstriction
Renin-angiotensin regulation of aldosterone production
Rho protein signal transduction
Cellular Location
Cell membrane
Involvement in disease
Renal tubular dysgenesis (RTD): Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Topology
Extracellular: 1-27 aa
Helical: 28-52 aa
Cytoplasmic: 53-64 aa
Helical: 65-87 aa
Extracellular: 88-102 aa
Helical: 103-124 aa
Cytoplasmic: 125-142 aa
Helical: 143-162 aa
Extracellular: 163-192 aa
Helical: 193-214 aa
Cytoplasmic: 215-240 aa
Helical: 241-262 aa
Extracellular: 263-275 aa
Helical: 276-296 aa
Cytoplasmic: 297-359 aa
PTM
C-terminal Ser or Thr residues may be phosphorylated.

Viering, D. H., Bech, A. P., de Baaij, J. H., Steenbergen, E. J., Danser, A. J., Wetzels, J. F., ... & Deinum, J. (2021). Functional tests to guide management in an adult with loss of function of type-1 angiotensin II receptor. Pediatric Nephrology, 1-7.

Zhang, Z., Yuan, Y., He, L., Yao, X., & Chen, J. (2020). Involvement of angiotensin II receptor type 1/NF‑κB signaling in the development of endometriosis. Experimental and therapeutic medicine, 20(4), 3269-3277.

Junusbekov, Y., Bayoglu, B., Cengiz, M., Dirican, A., & Arslan, C. (2020). AGT rs699 and AGTR1 rs5186 gene variants are associated with cardiovascular-related phenotypes in atherosclerotic peripheral arterial obstructive disease. Irish Journal of Medical Science (1971-), 189(3), 885-894.

Li, X., Wu, N., Ji, H., Huang, Y., Hu, H., Li, J., ... & Chen, X. (2020). A male-specific association between AGTR1 hypermethylation and coronary heart disease. Bosnian journal of basic medical sciences, 20(1), 31.

Zhang, K., Wiedemann, S., Dschietzig, M., Cremers, M. M., Augstein, A., Poitz, D. M., ... & Heidrich, F. M. (2020). The infarction zone rather than the noninfarcted remodeling zone overexpresses angiotensin II receptor type 1 and is the main source of ventricular atrial natriuretic peptide. Cardiovascular Pathology, 44, 107160.

Aoyagi, Y., Furuyama, T., Inoue, K., Matsuda, D., Matsubara, Y., Okahara, A., ... & Matsumoto, T. (2019). Attenuation of Angiotensin II–Induced Hypertension in BubR1 Low‐Expression Mice Via Repression of Angiotensin II Receptor 1 Overexpression. Journal of the American Heart Association, 8(23), e011911.

Zhao, Y., Xu, K., & Liu, P. (2018). Post-transcriptional control of angiotensin II type 1 receptor regulates osteosarcoma cell death. Cellular Physiology and Biochemistry, 45(4), 1581-1589.

Kim, J. Y., Oh, E., Kim, Y. J., Sung, D., Cho, T. M., Jang, S., & Seo, J. H. (2018). Blockage of angiotensin II type 1 receptor (AGTR1) inhibits epithelial-mesenchymal transition (EMT) and tumor growth in breast cancer.

Zhuang, Y., Niu, F., Liu, D., Sun, J., Zhang, X., Zhang, J., & Guo, S. (2018). Association between AGTR1 A1166C polymorphism and the susceptibility to diabetic nephropathy: Evidence from a meta-analysis. Medicine, 97(41).

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For research use only. Not intended for any clinical use.

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