Bak1

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

BCL2 Antagonist/Killer 1

Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.

Activation of cysteine-type endopeptidase activity Source: BHF-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
Aging Source: Ensembl
Animal organ regeneration Source: Ensembl
Apoptotic process Source: UniProtKB
Apoptotic process involved in blood vessel morphogenesis Source: Ensembl
Apoptotic signaling pathway Source: UniProtKB
B cell apoptotic process Source: Ensembl
B cell homeostasis Source: Ensembl
B cell negative selection Source: Ensembl
Blood vessel remodeling Source: Ensembl
Brain development Source: Ensembl
Cell population proliferation Source: Ensembl
Cellular response to mechanical stimulus Source: UniProtKB
Cellular response to unfolded protein Source: ParkinsonsUK-UCL
Cellular response to UV Source: UniProtKB
Endocrine pancreas development Source: Ensembl
Endoplasmic reticulum calcium ion homeostasis Source: UniProtKB
Establishment or maintenance of transmembrane electrochemical gradient Source: HGNC-UCL
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Fibroblast apoptotic process Source: Ensembl
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Limb morphogenesis Source: Ensembl
Mitochondrial fusion Source: Ensembl
Myeloid cell homeostasis Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
Negative regulation of gene expression Source: Ensembl
Negative regulation of peptidyl-serine phosphorylation Source: Ensembl
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of calcium ion transport into cytosol Source: Ensembl
Positive regulation of endoplasmic reticulum unfolded protein response Source: UniProtKB
Positive regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: Reactome
Positive regulation of protein-containing complex assembly Source: HGNC-UCL
Positive regulation of proteolysis Source: BHF-UCL
Positive regulation of release of cytochrome c from mitochondria Source: Ensembl
Post-embryonic camera-type eye morphogenesis Source: Ensembl
Regulation of cell cycle Source: Ensembl
Regulation of mitochondrial membrane permeability Source: BHF-UCL
Regulation of mitochondrial membrane potential Source: HGNC-UCL
Release of cytochrome c from mitochondria Source: BHF-UCL
Response to drug Source: Ensembl
Response to ethanol Source: Ensembl
Response to fungus Source: Ensembl
Response to gamma radiation Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to mycotoxin Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Response to UV-C Source: Ensembl
Thymocyte apoptotic process Source: Ensembl
Vagina development Source: Ensembl
Viral process Source: UniProtKB-KW

Mitochondrion outer membrane

Helical: 188-205 aa