BRSK1

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Thr-529 and Ser-579. Also regulates neuron polarization by mediating phosphorylation of WEE1 at Ser-642 in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at Ser-131, leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Full Name

BR Serine/Threonine Kinase 1

Function

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Biological Process

Associative learning Source: ARUK-UCL
Axonogenesis Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Cellular response to glucose starvation Source: GO_Central
Centrosome duplication Source: UniProtKB
Establishment of cell polarity Source: UniProtKB
G2/M transition of mitotic cell cycle Source: MGI
Intracellular signal transduction Source: GO_Central
Microtubule cytoskeleton organization involved in establishment of planar polarity Source: ARUK-UCL
Mitotic G2 DNA damage checkpoint Source: UniProtKB
Neuron differentiation Source: UniProtKB
Neurotransmitter secretion Source: UniProtKB
Peptidyl-serine phosphorylation Source: MGI
Protein phosphorylation Source: UniProtKB
Regulation of axonogenesis Source: ARUK-UCL
Regulation of neuron projection development Source: ARUK-UCL
Regulation of synaptic plasticity Source: ARUK-UCL
Regulation of synaptic vesicle clustering Source: ARUK-UCL
Response to UV Source: UniProtKB
Synaptic vesicle cycle Source: ARUK-UCL

Cellular Location

Centrosome; Nucleus; Cytoplasm; Synapse; Presynaptic active zone; Synaptic vesicle. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity).

PTM

Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C.