CALM1

CALM1 (Calmodulin 1) is a Protein Coding gene. Diseases associated with CALM1 include Long Qt Syndrome 14 and Ventricular Tachycardia, Catecholaminergic Polymorphic, 4. Among its related pathways are RET signaling and N-cadherin signaling events. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CALM3.

Calmodulin 1

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425).
Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269).
Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752).
Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).
Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029).
Acts as a sensor to modulate the endomplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335).
(Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity.

Activation of adenylate cyclase activity Source: Ensembl
Autophagosome membrane docking Source: UniProtKB
Chemical synaptic transmission Source: Reactome
Detection of calcium ion Source: BHF-UCL
Establishment of protein localization to mitochondrial membrane Source: Ensembl
Fc-epsilon receptor signaling pathway Source: Reactome
G2/M transition of mitotic cell cycle Source: Ensembl
Glycogen catabolic process Source: Reactome
G protein-coupled receptor signaling pathway Source: UniProtKB
Inositol phosphate metabolic process Source: Reactome
MAPK cascade Source: Reactome
Mitochondrion-endoplasmic reticulum membrane tethering Source: UniProtKB
Muscle contraction Source: Reactome
Negative regulation of high voltage-gated calcium channel activity Source: UniProtKB
Negative regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKB
Organelle localization by membrane tethering Source: UniProtKB
Platelet degranulation Source: Reactome
Positive regulation of cyclic-nucleotide phosphodiesterase activity Source: BHF-UCL
Positive regulation of DNA binding Source: Ensembl
Positive regulation of nitric-oxide synthase activity Source: Ensembl
Positive regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
Positive regulation of phosphoprotein phosphatase activity Source: BHF-UCL
Positive regulation of protein autophosphorylation Source: BHF-UCL
Positive regulation of protein dephosphorylation Source: BHF-UCL
Positive regulation of protein serine/threonine kinase activity Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Regulation of cardiac muscle cell action potential Source: UniProtKB
Regulation of cardiac muscle contraction Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Regulation of cytokinesis Source: UniProtKB
Regulation of heart rate Source: BHF-UCL
Regulation of nitric-oxide synthase activity Source: Reactome
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Regulation of rhodopsin mediated signaling pathway Source: Reactome
Regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKB
Regulation of synaptic vesicle endocytosis Source: Ensembl
Regulation of synaptic vesicle exocytosis Source: Ensembl
Response to amphetamine Source: Ensembl
Response to calcium ion Source: BHF-UCL
Response to corticosterone Source: Ensembl
Substantia nigra development Source: UniProtKB
Tetrahydrobiopterin metabolic process Source: Reactome
Viral process Source: UniProtKB-KW
Wnt signaling pathway, calcium modulating pathway Source: Reactome

Spindle; Spindle pole; Centrosome. Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4): An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT4 inheritance is autosomal dominant.
Long QT syndrome 14 (LQT14): A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

Ubiquitination results in a strongly decreased activity.
Phosphorylation results in a decreased activity.