CCAR1

CCAR1 (Cell Division Cycle And Apoptosis Regulator 1) is a Protein Coding gene. Diseases associated with CCAR1 include Dissociative Amnesia and Multiple Personality Disorder. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is CCAR2.

Full Name

Cell Division Cycle And Apoptosis Regulator 1

Function

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity).
May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952).
In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).

Biological Process

Apoptotic process Source: UniProtKB-KW
Cell cycle Source: UniProtKB-KW
mRNA splicing, via spliceosome Source: Reactome
Positive regulation of apoptotic process Source: MGI
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central

Cellular Location

Perinuclear region