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Mouse Anti-CCAR1 Recombinant Antibody (CBXC-1772) (CBMAB-C5516-CQ)

This product is a mouse antibody that recognizes CCAR1. The antibody CBXC-1772 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CCAR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1772
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cell Division Cycle And Apoptosis Regulator 1
Introduction
CCAR1 (Cell Division Cycle And Apoptosis Regulator 1) is a Protein Coding gene. Diseases associated with CCAR1 include Dissociative Amnesia and Multiple Personality Disorder. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is CCAR2.
Entrez Gene ID
55749
UniProt ID
Q8IX12
Alternative Names
Cell Division Cycle And Apoptosis Regulator 1; Cell Cycle And Apoptosis Regulatory Protein 1; Death Inducer With SAP Domain; CARP-1; CARP1; DIS;
Function
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity).
May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952).
In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).
Biological Process
Apoptotic process Source: UniProtKB-KW
Cell cycle Source: UniProtKB-KW
mRNA splicing, via spliceosome Source: Reactome
Positive regulation of apoptotic process Source: MGI
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of transcription, DNA-templated Source: GO_Central
Cellular Location
Perinuclear region

Westerheide, S. D., Lugano, D. I., Deonarine, A., & Park, M. A. (2021). CCAR-1 has a novel role in regulating the Caenorhabditis elegans germline.

Mondal, R., & Das, P. (2020). Novel aspects of Cell Division Cycle and Apoptosis Regulator 1 (CCAR1) protein in Morus notabilis: an in silico approach. Plant Signaling & Behavior, 15(10), 1795396.

Wang, F., Fan, M., Cai, Y., Zhou, X., Tai, S., Yu, Y., ... & Jin, X. (2020). Circular RNA circRIMS1 acts as a sponge of miR-433-3p to promote bladder cancer progression by regulating CCAR1 expression. Molecular Therapy-Nucleic Acids, 22, 815-831.

Li, D., Wang, L., Feng, J., Shen, Y. W., Liu, L. N., & Wang, Y. (2020). RP11‑284F21. 9 promotes lung carcinoma proliferation and invasion via the regulation of miR‑627‑3p/CCAR1. Oncology reports, 44(4), 1638-1648.

Johnson, G. S., Rajendran, P., & Dashwood, R. H. (2020). CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis. Cancer Science, 111(10), 3416.

Ge, Y., Tu, W., Li, J., Chen, X., Chen, Y., Xu, Y., ... & Liu, Y. (2020). MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1. Toxicology and applied pharmacology, 399, 115054.

Kanno, Y., Zhao, S., Yamashita, N., Saito, N., Ujiie, A., Iijima, R., ... & Inouye, Y. (2019). Cell cycle and apoptosis regulator 1, CCAR1, regulates enhancer-dependent nuclear receptor CAR transactivation. Molecular pharmacology, 95(1), 120-126.

Zhu, Y. J., Zheng, B., Luo, G. J., Ma, X. K., Lu, X. Y., Lin, X. M., ... & Chen, L. (2019). Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma. Theranostics, 9(12), 3526.

Zhu, Y. J., Zheng, B., Ma, X. K., Lu, X. Y., Lin, X. M., Luo, G. J., ... & Chen, L. (2018). Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma. bioRxiv, 396069.

Chang, T. S., Wei, K. L., Lu, C. K., Chen, Y. H., Cheng, Y. T., Tung, S. Y., ... & Chiang, M. K. (2017). Inhibition of CCAR1, a coactivator of β-catenin, suppresses the proliferation and migration of gastric cancer cells. International journal of molecular sciences, 18(2), 460.

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For research use only. Not intended for any clinical use.

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